Background Although several international guidelines recommend early over late intubation
of patients with severe coronavirus disease 2019 (COVID-19), this issue is still controversial …

The worldwide pandemic caused by the SARS-CoV-2 virus has resulted in over 84,407,000
cases, with over 1,800,000 deaths when this paper was submitted, with comorbidities such …

Background There is on-going controversy regarding the potential for increased respiratory
effort to generate patient self-inflicted lung injury (P-SILI) in spontaneously breathing …

Background Mechanical ventilation (MV) is a core intensive care unit (ICU) therapy.
Significant inter-and intra-patient variability in lung mechanics and condition makes …

Background: Optimal timing of initiation of invasive mechanical ventilation in patients with
acute hypoxemic respiratory failure due to COVID-19 is unknown. Thanks to early flattening …

Due to the SARS-CoV-2 infection–related severe pulmonary tissue damages associated
with a relative specific widespread thrombotic microangiopathy, the pathophysiologic role of …

Background We hypothesized that as CARDS may present different pathophysiological
features than classic ARDS, the application of high levels of end-expiratory pressure is …

Severe acute respiratory syndrome coronavirus-2 (SARS-CoV-2), later renamed coronavirus
disease 2019 (COVID-19), was first identified in Wuhan, China, in early December 2019 …

Objectives: Clinical observation suggests that early acute respiratory distress syndrome
induced by the severe acute respiratory syndrome coronavirus 2 may be “atypical” due to a …

Introduction Acute respiratory distress syndrome (ARDS) due to coronavirus disease 2019
(COVID-19) often leads to mortality. Outcomes of patients with COVID-19-related ARDS …