Members of the genus Pseudomonas inhabit a wide variety of environments, which is
reflected in their versatile metabolic capacity and broad potential for adaptation to fluctuating …

Essential genes encode the processes that are necessary for life. Until recently, commonly
applied binary classifications left no space between essential and non-essential genes. In …

The Pseudomonas aeruginosa genome (G+ C content 65–67%, size 5.5–7 Mbp) is made up
of a single circular chromosome and a variable number of plasmids. Sequencing of …

Essential genes are thought to be critical for the survival of the organisms under certain
circumstances and the natural selection acting on essential genes is expected to be stricter …

Methods for rapid and reliable microbial identification are essential in modern healthcare.
The ability to detect and correctly identify pathogenic species and their resistance phenotype …

Phenotypic variability among bacteria depends on gene expression in response to different
environments, and it also reflects differences in genomic structure. In this study, we analyzed …

Extensive use of next-generation sequencing (NGS) for pathogen profiling has the potential
to transform our understanding of how genomic plasticity contributes to phenotypic …

Environment is recognized as a huge reservoir for bacterial species and a source of human
pathogens. Some environmental bacteria have an extraordinary range of activities that …

Gram-negative bacilli Pseudomonas aeruginosa is an important pathogen in hospitalized
patients, contributing to their morbidity and mortality due to its multiple resistance …

Identification of essential genes is critical to understanding the physiology of a species,
proposing novel drug targets and uncovering minimal gene sets required for life. Although …