There is no doubt that significant progress has been made in tumor therapy in the past
decades. However, the discovery of new molecules with potential antitumor properties still …

Eleutherococcus sessiliflorus (Rupr. & Maxim.) SY Hu (E. sessiliflorus), a member of the
Araliaceae family, is a valuable plant widely used for medicinal and dietary purposes. The …

Overexpression of survivin is frequently observed in human malignancies and is associated
with poor prognosis. The present study found that survivin is highly expressed in …

PD-L1 (programmed cell death ligand 1) is frequently up-regulated in tumors and is critical
in tumor immune escape. In addition to antibodies that block the interaction between PD-L1 …

Pancreatic cancer is the third leading cause of cancer‐related deaths in the United States,
owing to its aggressive nature and suboptimal treatment options, emphasizing the need for …

The cyclic nucleotides, cAMP and cGMP, are ubiquitous second messengers responsible for
translating extracellular signals to intracellular biological responses in both normal and …

Immune abnormality involves in various diseases, such as infection, allergic diseases,
autoimmune diseases, as well as transplantation. Several signal pathways have been …

Abstract Heat shock protein 90 (Hsp90) is a predominant member among Heat shock
proteins (HSPs), playing a central role in cellular protection and maintenance by aiding in …

Ocular cancers represent a rare pathology. The American Cancer Society estimates that
3,360 cases of ocular cancer occur annually in the United States. The major types of cancers …

Abstract p53 is a transcription factor that activates the expression of various genes involved
in the maintenance of genomic stability, and more than 50% of cancers harbor inactivating …