Single-strand annealing (SSA) is a DNA double-strand break (DSB) repair pathway that
uses homologous repeats to bridge DSB ends. SSA involving repeats that flank a single …

DNA double strand breaks (DSB) are the most deleterious lesions for the integrity of the
genome, as their misrepair can lead to the formation of chromosome translocations. Cells …

Unlike copy number variants (CNVs), inversions remain an underexplored genetic variation
class. By integrating multiple genomic technologies, we discover 729 inversions in 41 …

CRISPR/Cas9-based genome editing has revolutionized experimental molecular biology
and entered the clinical world for targeted gene therapy. Identifying DNA modifications …

Abstract Long interspersed element 1 (LINE-1) is the only protein-coding transposon that is
active in humans. LINE-1 propagates in the genome using RNA intermediates via …

Heavy metals such as cadmium, arsenic and nickel are classified as carcinogens. Although
the precise mechanism of carcinogenesis is undefined, heavy metal exposure can …

Transposable elements constitute about half of human genomes, and their role in
generating human variation through retrotransposition is broadly studied and appreciated …

Transposable elements (TEs) are recognized as major players in genome plasticity and
evolution. The high abundance of TEs in the human genome, especially the Alu and Long …

DNA double-strand breaks (DSBs) are rare, but highly toxic, lesions requiring orchestrated
and conserved machinery to prevent adverse consequences, such as cell death and cancer …

Alu elements, the short interspersed element numbering more than 1 million copies per
human genome, can mediate the formation of copy number variants (CNVs) between …