[HTML][HTML] Pluripotent stem cell-based cell therapy—promise and challenges
S Yamanaka - Cell stem cell, 2020 - cell.com
Human pluripotent stem cells such as embryonic stem cells (ESCs) and induced pluripotent
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …
stem cells (iPSCs) provide unprecedented opportunities for cell therapies against intractable …
Human organoids: model systems for human biology and medicine
The historical reliance of biological research on the use of animal models has sometimes
made it challenging to address questions that are specific to the understanding of human …
made it challenging to address questions that are specific to the understanding of human …
Blastocyst-like structures generated from human pluripotent stem cells
Limited access to embryos has hampered the study of human embryogenesis and disorders
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
that occur during early pregnancy. Human pluripotent stem cells provide an alternative …
Rolling back human pluripotent stem cells to an eight-cell embryo-like stage
After fertilization, the quiescent zygote experiences a burst of genome activation that initiates
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
a short-lived totipotent state. Understanding the process of totipotency in human cells would …
[HTML][HTML] 3D-cultured blastoids model human embryogenesis from pre-implantation to early gastrulation stages
Naive human pluripotent stem cells have the remarkable ability to self-organize into
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …
blastocyst-like structures (" blastoids") that model lineage segregation in the pre …
Advances in pluripotent stem cells: history, mechanisms, technologies, and applications
G Liu, BT David, M Trawczynski, RG Fessler - Stem cell reviews and …, 2020 - Springer
Over the past 20 years, and particularly in the last decade, significant developmental
milestones have driven basic, translational, and clinical advances in the field of stem cell …
milestones have driven basic, translational, and clinical advances in the field of stem cell …
Mammalian in vitro gametogenesis
M Saitou, K Hayashi - Science, 2021 - science.org
BACKGROUND Mammalian germ cells differentiate into oocytes in females and
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
spermatozoa in males. An oocyte and a spermatozoon fuse to form a zygote and then …
Cynomolgus monkey embryo model captures gastrulation and early pregnancy
J Li, Q Zhu, J Cao, Y Liu, Y Lu, Y Sun, Q Li, Y Huang… - Cell Stem Cell, 2023 - cell.com
Human stem cell-derived blastoids display similar morphology and cell lineages to normal
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
blastocysts. However, the ability to investigate their developmental potential is limited. Here …
Capturing human trophoblast development with naive pluripotent stem cells in vitro
S Io, M Kabata, Y Iemura, K Semi, N Morone… - Cell stem cell, 2021 - cell.com
Trophoblasts are extraembryonic cells that are essential for maintaining pregnancy. Human
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …
trophoblasts arise from the morula as trophectoderm (TE), which, after implantation …
Dissecting peri-implantation development using cultured human embryos and embryo-like assembloids
Z Ai, B Niu, Y Yin, L Xiang, G Shi, K Duan, S Wang… - Cell Research, 2023 - nature.com
Studies of cultured embryos have provided insights into human peri-implantation
development. However, detailed knowledge of peri-implantation lineage development as …
development. However, detailed knowledge of peri-implantation lineage development as …