Mipomersen is a second generation antisense oligonucleotide that targets apolipoprotein B.
It has been studied thoroughly in clinical trials (more than 800 subjects), including four …

Chylomicrons are lipoproteins synthesized exclusively by the intestine to transport dietary fat
and fat-soluble vitamins. Synthesis of apoB48, a translational product of the apob gene, is …

The pharmacokinetics of a 2′-O-(2-methoxyethyl)-modified oligonucleotide, ISIS 301012
[targeting human apolipoprotein B-100 (apoB-100)], was characterized in mouse, rat …

Apolipoproteins B, CIII, and AII are synthesized primarily in the liver and intestine and play
an important role in lipid and cholesterol metabolism. It was previously shown that the cis …

High levels of plasma apolipoprotein B-100 (apoB-100), the principal apolipoprotein of LDL,
are associated with cardiovascular disease. We hypothesized that suppression of apoB-100 …

Publisher Summary Apolipoprotein B plays an essential role in lipoprotein biosynthesis. This
chapter discusses the structure and function of apoliprotein B (apoB) and attempts to relate …

The in vivo pharmacokinetics/pharmacodynamics of 2′-O-(2-methoxyethyl)(2′-MOE)
modified antisense oligonucleotides (ASOs), targeting apolipoprotein B-100 (apoB-100) …

in Synthesis and secretion of hepatic apolipoprotein B-conta lipoproteins ing Page 1
BiochimicaL et Biophysics &ta ELSEVIER Biochimica et Biophysics Acta 1212 (1994) 152-166 …

Several hormones, including insulin, glucagon, and glucocorticoids, regulate the expression
of the rate-limiting gluconeogenic enzyme, phosphoenolpyruvate carboxykinase [GTP …

Lipoproteins are macromolecular complexes of lipids and proteins which originate mainly
from the liver and intestine, and are involved in the transport and redistribution of lipids in the …