Inflammatory pathways in heart failure with preserved left ventricular ejection fraction: implications for future interventions

NR Pugliese, P Pellicori, F Filidei… - Cardiovascular …, 2022 - academic.oup.com
Many patients with symptoms and signs of heart failure have a left ventricular ejection
fraction≥ 50%, termed heart failure with preserved ejection fraction (HFpEF). HFpEF is a …

[HTML][HTML] Diminished α7 nicotinic acetylcholine receptor (α7nAChR) rescues amyloid-β induced atrial remodeling by oxi-CaMKII/MAPK/AP-1 axis-mediated …

J Zhao, L Yu, X Xue, Y Xu, T Huang, D Xu, Z Wang… - Redox Biology, 2023 - Elsevier
The potential coexistence of Alzheimer's disease (AD) and atrial fibrillation (AF) is
increasingly common as aging-related diseases. However, little is known about mechanisms …

Biomarker signature and pathophysiological pathways in patients with chronic heart failure and metabolic syndrome

CCS van der Hoef, EM Boorsma… - European Journal of …, 2023 - Wiley Online Library
Aim The comorbidities that collectively define metabolic syndrome are common in patients
with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart …

IGFBP-7 and outcomes in heart failure with reduced ejection fraction: findings from DAPA-HF

C Adamson, P Welsh, KF Docherty, RA de Boer… - Heart Failure, 2023 - jacc.org
Background Insulin-like growth factor–binding protein-7 (IGFBP-7) has been proposed as a
potential prognostic biomarker in heart failure (HF), but the association between elevation in …

Integrative proteomic analyses across common cardiac diseases yield new mechanistic insights and enhanced prediction

A Schuermans, AB Pournamdari, J Lee, R Bhukar… - medRxiv, 2023 - medrxiv.org
Cardiac diseases represent common highly morbid conditions for which underlying
molecular mechanisms remain incompletely understood. Here, we leveraged 1,459 protein …

Common disease-promoting signalling pathways in heart failure and atrial fibrillation: putative underlying mechanisms and potential therapeutic consequences

JA Keefe, XHT Wehrens, D Dobrev - Cardiovascular Research, 2022 - academic.oup.com
Atrial fibrillation (AF) and heart failure (HF) are common, progressive diseases that often co-
exist. Common epidemiological risk factors and structural alterations such as chamber …

Tissue-resident memory T cells in Epicardial adipose tissue comprise transcriptionally distinct subsets that are modulated in Atrial Fibrillation

P Longhi, V Vyas, B Sandhar, E Wood, H Blythe… - 2023 - researchsquare.com
Atrial fibrillation (AF) is the most common sustained arrhythmia and carries an increased risk
of stroke and heart failure. Here, we investigate how the immune infiltrate of human …

Biomarker signature and pathophysiological pathways in chronic heart failure patients with metabolic syndrome.

C van der Hoef, EM Boorsma, JE Emmens… - 2023 - figshare.le.ac.uk
AimThe comorbidities that collectively define metabolic syndrome are common in patients
with heart failure. However, the role of metabolic syndrome in the pathophysiology of heart …

[PDF][PDF] Notch-зависимые механизмы функциональной регуляции мезенхимных клеток сердца при остром инфаркте и пороках развития

АБ Малашичева - disser.spbu.ru
Сердечно-сосудистые заболевания находятся на первом месте среди причин
инвалидизации и смертности в мире [1, 2]. По последним оценкам Всемирной …

[PDF][PDF] Pavel Mikhailovich Doсshin

MA Borisovna - disser.spbu.ru
Cardiovascular diseases rank first among the causes of disability and mortality worldwide [1,
2]. According to the latest estimates by the World Health Organization, approximately 17.9 …