Recent evidence indicates that Parkinson's disease and diabetes, both age-related chronic
diseases, share remarkably similar dysregulated pathways. Exposure to environmental …

Survival of human peripheral nervous system neurons and associated distal axons is highly
dependent on energy. Diabetes invokes a maladaptation in glucose and lipid energy …

Background Trimethylamine‐N‐oxide (TMAO) has recently been identified as a novel and
independent risk factor for promoting atherosclerosis through inducing vascular …

Background Obesity is associated with vitamin D deficiency, and both are areas of active
public health concern. We explored the causality and direction of the relationship between …

Excessive generation of mitochondrial reactive oxygen species (ROS) is considered to be
initiating event in the development of diabetic nephropathy (DN). Mitochondrial biosynthesis …

The AMPK/PGC-1α pathway-mediated mitochondrial dysfunction has been supposed to
play a crucial role in pathogenesis of diabetic peripheral neuropathy (DPN). The present …

Mitochondrial reactive oxygen species (mtROS) homeostasis plays an essential role in
preventing oxidative injury in endothelial cells, an initial step in atherogenesis. Resveratrol …

Modulation of endogenous cellular defense mechanisms via the vitagene system represents
an innovative approach to therapeutic intervention in diseases causing chronic tissue …

Diabetic neuropathy is a dying back neurodegenerative disease of the peripheral nervous
system where mitochondrial dysfunction has been implicated as an etiological factor …

Significance: This review highlights the many intracellular processes generating reactive
oxygen species (ROS) in the peripheral nervous system in the context of type 1 diabetes …