Recent drug design strategies and identification of key heterocyclic scaffolds for promising anticancer targets
A Mushtaq, P Wu, MM Naseer - Pharmacology & Therapeutics, 2023 - Elsevier
Cancer, a noncommunicable disease, is the leading cause of mortality worldwide and is
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
anticipated to rise by 75% in the next two decades, reaching approximately 25 million cases …
New thiazolidine-2, 4-diones as effective anti-proliferative and anti-VEGFR-2 agents: Design, synthesis, in vitro, docking, MD simulations, DFT, ADMET, and toxicity …
Abstract Novel thiazolidine-2, 4-dione derivatives, 11a-g, were designed, and synthesized
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
targeting the VEGFR-2 protein. The in vitro studies indicated the abilities of the synthesized …
In-silico design, pharmacophore-based screening, and molecular docking studies reveal that benzimidazole-1,2,3-triazole hybrids as novel EGFR inhibitors targeting …
Lung cancer is a complex and heterogeneous disease, which has been associated with
various molecular alterations, including the overexpression and mutations of the epidermal …
various molecular alterations, including the overexpression and mutations of the epidermal …
Indoloquinazoline alkaloids suppress angiogenesis and inhibit metastasis of melanoma cells
X Guo, A Fan, X Qi, D Liu, J Huang, W Lin - Bioorganic Chemistry, 2023 - Elsevier
Metastasis is the leading cause of cancer-related mortality, targeting angiogenesis emerges
as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new …
as a therapeutic strategy for the treatment of melanoma metastasis. Discovery of new …
[HTML][HTML] Computer-assisted drug discovery (CADD) of an anti-cancer derivative of the theobromine alkaloid inhibiting VEGFR-2
VEGFR-2 is a significant target in cancer treatment, inhibiting angiogenesis and impeding
tumor growth. Utilizing the essential pharmacophoric structural properties, a new semi …
tumor growth. Utilizing the essential pharmacophoric structural properties, a new semi …
Discovery of A Novel Series of Quinazoline–Thiazole Hybrids as Potential Antiproliferative and Anti-Angiogenic Agents
Considering the pivotal role of angiogenesis in solid tumor progression, we developed a
novel series of quinazoline–thiazole hybrids (SA01–SA07) as antiproliferative and anti …
novel series of quinazoline–thiazole hybrids (SA01–SA07) as antiproliferative and anti …
[Cell@Al2O3(HEPiPY)]DCA: A Cellulose Supported Ionic Liquid Catalyst for Synthesis of 11 b,12‐dihydro‐6H,13Hbenzo[5,6][1,3]oxazino[3,4‐a]quinazoline‐6,13‐dione …
VB Shinde, PM Mhaldar, MV Patil, M Mirzaei… - …, 2024 - Wiley Online Library
In present study we have designed and synthesized novel cellulose supported ionic liquid
catalyst (CSILC),[Cell@ Al2O3 (HEPiPY)] DCA and explored its catalytic efficiency for …
catalyst (CSILC),[Cell@ Al2O3 (HEPiPY)] DCA and explored its catalytic efficiency for …