Since its inception in 1995, the biopharmaceutical classification system (BCS) has become
an increasingly important tool for regulation of drug products world-wide. Until now …

This article reviews the information available to assist pharmacokineticists in the prediction
of metabolic drug interactions. Significant advances in this area have been made in the last …

In drug discovery and nonclinical development the volume of distribution at steady state (V
ss) of each novel drug candidate is commonly determined under in vivo conditions …

The human intestinal absorption of 241 drugs was evaluated. Three main methods were
used to determine the human intestinal absorption: bioavailability, percentage of urinary …

Purpose To study the correlation of intestinal absorption for drugs with various absorption
routes between human and rat, and to explore the underlying molecular mechanisms for the …

Captopril, an inhibitor of angiotensin converting enzyme, is widely used clinically to manage
hypertension and congestive heart failure. Here captopril is shown to be an inhibitor of …

Chickpea (Cicer arietinum L.) peptides have shown in vitro potential to inhibit the
angiotensin I-converting enzyme (ACE-I). However, the potential molecular interactions …

Diabetes mellitus is a serious metabolic disorder characterized by abnormal blood glucose
levels in the body. The development of therapeutic strategies for restoring and maintaining …

Technologies currently employed to find and identify drug metabolites in complex biological
matrices generally yield results that offer a comprehensive picture of the drug metabolite …

The advancement in the processing speeds of computing machines has facilitated the
development of complex physiologically based pharmacokinetic (PBPK) models. These …