Antibiotic resistance (AR) remains one of the leading global health challenges, mostly
implicated in disease-related deaths. The Enterobacteriaceae-producing metallo-β …

The cAMP-responsive element binding protein (CREB) binding protein (CBP), a
bromodomain-containing protein, engages with multiple transcription factors and enhances …

In the antibacterial arsenal, β-lactams have held a prominent position, but increasing
resistance due to unauthorized use and genetic factors requires new strategies. Combining …

With significant human and economic losses, increasing bacterial resistance is a serious
global threat to human life. Due to their high efficacy, broad spectrum, and cost …

Discovering novel NDM-1 inhibitors is an urgent task for treatment of 'superbug'infectious
diseases. In this study, we found that naturally occurring houttuynin and its sulfonate …

The effectiveness of all antibiotics in the β-lactam group to cure bacterial infections has been
impaired by the introduction of the New Delhi Metallo-β-lactamase (NDM-1) enzyme …

Red flour beetle, Tribolium castaneum, has a major negative impact during storage of
agricultural products and reveals the negative impacts on human health. Insect-specific …

Abstract Metallo‐β‐lactamases (MBLs), enzymes of class B, employ zinc ions to degrade β‐
lactam antibiotics such as penicillins, cephalosporins, carbapenems, and cephamycins …

Estimation of Bond Free Energy with gmx_MMPBSA in NDM-1 Complexes Page 1 067
Citation: Valencia E, Galvis M. Estimation of Bond Free Energy with gmx_MMPBSA in NDM-1 …

Bacterial and viral infections have posed serious threats to human health since time
immemorial, occasionally causing pandemics, yet with therapeutic challenges due to …