Disease modification in inflammatory skin disorders: opportunities and challenges

T Bieber - Nature Reviews Drug Discovery, 2023 - nature.com
Progress in understanding of the mechanisms underlying chronic inflammatory skin
disorders, such as atopic dermatitis and psoriasis vulgaris, has led to new treatment options …

[HTML][HTML] The role of the interleukin-36 axis in generalized pustular psoriasis: a review of the mechanism of action of spesolimab

JE Hawkes, S Visvanathan, JG Krueger - Frontiers in Immunology, 2023 - frontiersin.org
Generalized pustular psoriasis (GPP) is a rare, chronic, inflammatory skin disorder
characterized by recurrent flares associated with skin erythema, desquamation, and …

Efficacy and safety of subcutaneous spesolimab for the prevention of generalised pustular psoriasis flares (Effisayil 2): an international, multicentre, randomised …

A Morita, B Strober, AD Burden, SE Choon, MJ Anadkat… - The Lancet, 2023 - thelancet.com
Background Spesolimab is an anti-interleukin-36 receptor monoclonal antibody approved to
treat generalised pustular psoriasis (GPP) flares. We aimed to assess the efficacy and safety …

Health‐related quality of life in patients with generalized pustular psoriasis: A systematic literature review

SE Choon, C De La Cruz, P Wolf… - Journal of the …, 2024 - Wiley Online Library
Generalized pustular psoriasis (GPP) is a rare, chronic, neutrophilic inflammatory skin
disease characterized by episodes of widespread eruption of sterile, macroscopic pustules …

[HTML][HTML] Clinical and Disease Burden of Patients with Generalized Pustular Psoriasis: A Review of Real-World Evidence

T Bhutani, AS Farberg - Dermatology and Therapy, 2024 - Springer
Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening
disease. There is limited understanding of patient characteristics in GPP and their …

Generalized Pustular Psoriasis, Acute Generalized Exanthematous Pustulosis, and Other Pustular Reactions: A Clinical Review

E Gössinger, R Dodiuk-Gad, B Mühleisen… - Dermatologic …, 2024 - derm.theclinics.com
Few skin conditions are as distinctively memorable as generalized pustular psoriasis (GPP),
acute generalized exanthematous pustulosis (AGEP), and other pustular reactions. 1, 2 …

Spesolimab for generalized pustular psoriasis: a review of two key clinical trials supporting initial US regulatory approval

EC Gwillim, AJ Nichols - Frontiers in Immunology, 2024 - frontiersin.org
Generalized pustular psoriasis (GPP) is a chronic, rare, and potentially life-threatening
inflammatory disease, characterized by the rapid and widespread eruption of small, sterile …

Exploring the clinical assessment, guidelines, and options for the treatment of generalized pustular psoriasis [podcast]

EJ Song, C Liu - Clinical, Cosmetic and Investigational …, 2023 - Taylor & Francis
Acute episodes of generalized pustular psoriasis (GPP), known as “flares”, are characterized
by the widespread appearance of pustules with surrounding skin erythema, and are often …

[HTML][HTML] Generalized Pustular Psoriasis and Systemic Organ Dysfunctions

R Teshima, N Saito-Sasaki, Y Sawada - International Journal of …, 2024 - mdpi.com
This review explores the intricate relationship between generalized pustular psoriasis (GPP)
and various systemic diseases, shedding light on the broader impacts of this severe skin …

[HTML][HTML] Current Treatments for Generalized Pustular Psoriasis: A Narrative Summary of a Systematic Literature Search

L Puig, H Fujita, D Thaçi, M Zheng… - Dermatology and …, 2024 - Springer
Generalized pustular psoriasis (GPP) is a rare, chronic and potentially life-threatening
autoinflammatory skin disease characterized by widespread eruption of sterile pustules, with …