Maintaining the chemical integrity of DNA in the face of assault by oxidizing agents is a
constant challenge for living organisms. Base-excision repair has an important role in …

Colorectal cancer (CRC) is the second most common newly diagnosed cancer and accounts
for the second highest number of cancer related deaths in Australia, the third worldwide and …

Disclaimer: The practice guidelines of the American College of Medical Genetics and
Genomics (ACMG) and the National Society of Genetic Counselors (NSGC) are developed …

The genetic cause underlying the development of multiple colonic adenomas, the
premalignant precursors of colorectal cancer (CRC), frequently remains unresolved in …

Oxoguanine, a common mutagenic DNA lesion, generates G: C> T: A transversions via
mispairing with adenine during DNA replication. When operating normally, the MUTYH DNA …

▪ Abstract Living organisms dependent on water and oxygen for their existence face the
major challenge of faithfully maintaining their genetic material under a constant attack from …

Oxidative DNA damage constitutes a major threat to genetic integrity, and has thus been
implicated in the pathogenesis of a wide variety of diseases, including cancer and …

The past two decades have brought many important advances in our understanding of the
hereditary susceptibility to cancer. Approximately 5–10% of all cancers are inherited, the …

Colorectal cancer (CRC) is a complex disease that develops as a consequence of both
genetic and environmental risk factors. A small proportion (3–5%) of cases arise from …

Familial adenomatous polyposis (FAP) is an inherited disorder that represents the most
common gastrointestinal polyposis syndrome. Germline mutations in the APC gene were …