Nonlinear and stochastic dynamics in the heart
In a normal human life span, the heart beats about 2–3 billion times. Under diseased
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
conditions, a heart may lose its normal rhythm and degenerate suddenly into much faster …
The physics of heart rhythm disorders
WJ Rappel - Physics reports, 2022 - Elsevier
The global burden caused by cardiovascular disease is substantial, with heart disease
representing the most common cause of death around the world. There remains a need to …
representing the most common cause of death around the world. There remains a need to …
Cardiac alternans: from bedside to bench and back
Cardiac alternans arises from dynamical instabilities in the electrical and calcium cycling
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
systems of the heart, and often precedes ventricular arrhythmias and sudden cardiac death …
Mechanisms of ventricular arrhythmias: from molecular fluctuations to electrical turbulence
Ventricular arrhythmias have complex causes and mechanisms. Despite extensive
investigation involving many clinical, experimental, and computational studies, effective …
investigation involving many clinical, experimental, and computational studies, effective …
Role of sodium and calcium dysregulation in tachyarrhythmias in sudden cardiac death
Despite improvements in the therapy of underlying heart disease, sudden cardiac death is a
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …
major cause of death worldwide. Disturbed Na and Ca handling is known to be a major …
Potassium currents in the heart: functional roles in repolarization, arrhythmia and therapeutics
N Chiamvimonvat, Y Chen‐Izu… - The Journal of …, 2017 - Wiley Online Library
This is the second of the two White Papers from the fourth UC Davis Cardiovascular
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
Symposium Systems Approach to Understanding Cardiac Excitation–Contraction Coupling …
Multi-scale modeling in biology: how to bridge the gaps between scales?
Human physiological functions are regulated across many orders of magnitude in space and
time. Integrating the information and dynamics from one scale to another is critical for the …
time. Integrating the information and dynamics from one scale to another is critical for the …
Optical Mapping of Sarcoplasmic Reticulum Ca2+ in the Intact Heart: Ryanodine Receptor Refractoriness During Alternans and Fibrillation
Rationale: Sarcoplasmic reticulum (SR) Ca2+ cycling is key to normal excitation–contraction
coupling but may also contribute to pathological cardiac alternans and arrhythmia …
coupling but may also contribute to pathological cardiac alternans and arrhythmia …
Plasticizer interaction with the heart: chemicals used in plastic medical devices can interfere with cardiac electrophysiology
R Jaimes III, D McCullough, B Siegel… - Circulation …, 2019 - Am Heart Assoc
Background: Phthalates are used as plasticizers in the manufacturing of flexible, plastic
medical products. Patients can be subjected to high phthalate exposure through contact with …
medical products. Patients can be subjected to high phthalate exposure through contact with …
A technical review of optical mapping of intracellular calcium within myocardial tissue
Optical mapping of Ca2+-sensitive fluorescence probes has become an extremely useful
approach and adopted by many cardiovascular research laboratories to study a spectrum of …
approach and adopted by many cardiovascular research laboratories to study a spectrum of …