[HTML][HTML] Microbiota of the gastrointestinal tract: Friend or foe?

MA Senchukova - World Journal of Gastroenterology, 2023 - ncbi.nlm.nih.gov
The gut microbiota is currently considered an external organ of the human body that
provides important mechanisms of metabolic regulation and protection. The gut microbiota …

The microbiota–gut–brain axis in Huntington's disease: pathogenic mechanisms and therapeutic targets

MN Ekwudo, C Gubert, AJ Hannan - The FEBS Journal, 2024 - Wiley Online Library
Huntington's disease (HD) is a currently incurable neurogenerative disorder and is typically
characterized by progressive movement disorder (including chorea), cognitive deficits …

Gasdermin D deficiency in vascular smooth muscle cells ameliorates abdominal aortic aneurysm through reducing putrescine synthesis

J Gao, Y Chen, H Wang, X Li, K Li, Y Xu… - Advanced …, 2023 - Wiley Online Library
Abdominal aortic aneurysm (AAA) is a common vascular disease associated with significant
phenotypic alterations in vascular smooth muscle cells (VSMCs). Gasdermin D (GSDMD) is …

Spermidine dietary supplementation and polyamines level in reference to survival and lifespan of honey bees

S Đorđievski, EL Vukašinović, TV Čelić, I Pihler… - Scientific reports, 2023 - nature.com
Honey bee health has been an important and ongoing topic in recent years. Honey bee is
also an important model organism for aging studies. Polyamines, putrescine, spermidine …

The involvement of polyamines catabolism in the crosstalk between neurons and astrocytes in neurodegeneration

M Cervelli, M Averna, L Vergani, M Pedrazzi, S Amato… - Biomedicines, 2022 - mdpi.com
In mammalian cells, the content of polyamines is tightly regulated. Polyamines, including
spermine, spermidine and putrescine, are involved in many cellular processes. Spermine …

[HTML][HTML] Modulating the polyamine/hypusine axis controls generation of CD8+ tissue-resident memory T cells

AG Elmarsafawi, RS Hesterberg, MR Fernandez… - JCI insight, 2023 - ncbi.nlm.nih.gov
Glutaminolysis is a hallmark of the activation and metabolic reprogramming of T cells.
Isotopic tracer analyses of antigen-activated effector CD8+ T cells revealed that glutamine is …

Conformational cycle of human polyamine transporter ATP13A2

J Mu, C Xue, L Fu, Z Yu, M Nie, M Wu, X Chen… - Nature …, 2023 - nature.com
Dysregulation of polyamine homeostasis strongly associates with human diseases.
ATP13A2, which is mutated in juvenile-onset Parkinson's disease and autosomal recessive …

[HTML][HTML] P5B-ATPases in the mammalian polyamine transport system and their role in disease

M Azfar, S van Veen, M Houdou, NN Hamouda… - … et Biophysica Acta (BBA …, 2022 - Elsevier
Polyamines (PAs) are physiologically relevant molecules that are ubiquitous in all
organisms. The vitality of PAs to the healthy functioning of a cell is due to their polycationic …

Physicochemical and thermal characteristics of onion skin from fifteen Indian cultivars for possible food applications

NA Sagar, A Khar, Vikas, A Tarafdar… - Journal of Food …, 2021 - Wiley Online Library
Every year tons of onion waste is produced worldwide. The dried outer onion skin
contributed up to 70% of this waste. Outer‐dried skins of fifteen prominent onion cultivars …

Obesity and its impact on female reproductive health: Unraveling the connections

L Zheng, L Yang, Z Guo, N Yao, S Zhang… - Frontiers in …, 2024 - frontiersin.org
In the modern era, the escalating global prevalence of obesity has profound implications on
female reproductive health. Obesity, transcending mere lifestyle choices, has evolved into a …