Corticostriatal connections play a central role in developing appropriate goal-directed
behaviors, including the motivation and cognition to develop appropriate actions to obtain a …

Exercise interventions in individuals with Parkinson's disease incorporate goal-based motor
skill training to engage cognitive circuitry important in motor learning. With this exercise …

Basolateral amygdala (BLA) principal cells are capable of driving and antagonizing
behaviors of opposing valence. BLA neurons project to the central amygdala (CeA), which …

The lamprey belongs to the phylogenetically oldest group of vertebrates that diverged from
the mammalian evolutionary line 560 million years ago. A comparison between the lamprey …

Parkinson's disease is a chronic progressive neurodegenerative disorder characterized by
resting tremor, slowness of movements, rigidity, gait disturbance and postural instability …

How do our brains determine whether something is good or bad? How is this computational
goal implemented in biological systems? Given the critical importance of valence processing …

Huntington's disease (HD) is an autosomal neurodegenerative disease that is characterized
by an excessive number of CAG trinucleotide repeats within the huntingtin gene (HTT). HD …

Neural circuits of the basal ganglia are critical for motor planning and action selection,,. Two
parallel basal ganglia pathways have been described, and have been proposed to exert …

A better understanding of the neural systems underlying impulse control is important for
psychiatry. Although most impulses are motivational or emotional rather than motoric per se …

Optogenetic tools have provided a new way to establish causal relationships between brain
activity and behaviour in health and disease. Although no animal model captures human …