ApoE is the major lipid and cholesterol carrier in the CNS. There are three major human
polymorphisms, apoE2, apoE3, and apoE4, and the genetic expression of APOE4 is one of …

Multiple modes of cell death have been identified, each with a unique function and each
induced in a setting-dependent manner. As billions of cells die during mammalian …

Lipid metabolism has been associated with the cyclic guanosine monophosphate (GMP)-
AMP synthase (cGAS) stimulator of interferon genes (STING) DNA-sensing pathway, but our …

Rett syndrome (RTT) is a neurological disorder caused by mutations in the X-linked gene
methyl-CpG-binding protein 2 (MECP2), a ubiquitously expressed transcriptional regulator …

The gut microbiota regulates key hepatic functions, notably through the production of
bacterial metabolites that are transported via the portal circulation. We evaluated the effects …

Nuclear receptors (NRs) are transcription factors actively involved in many aspects of human
physiology and pathology, serving as sensors of stimuli, master regulators of downstream …

Sterol regulator element binding proteins (SREBPs) are a family of transcription factors
involved in the biogenesis of cholesterol, fatty acids and triglycerides. They also regulate …

Type-2 diabetes (T2D) is a disease of two etiologies: metabolic and inflammatory. At the
cross-section of these etiologies lays the phenomenon of metabolic inflammation. Whilst …

Macrophages acquire anti-inflammatory and proresolving functions to facilitate resolution of
inflammation and promote tissue repair. While alternatively activated macrophages (AAMs) …

Background The macrophage theory of depression states that macrophages play an
important role in Major Depressive Disorder (MDD). Methods MDD patients (N= 140) and …