Interleukin (IL)-33 belongs to IL-1 cytokine family which is constitutively produced from the
structural and lining cells including fibroblasts, endothelial cells, and epithelial cells of skin …

Monoclonal antibody therapies have significantly improved treatment outcomes for patients
with severe asthma; however, a significant disease burden remains. Available biologic …

Abstract Interleukin (IL)-33 is a broad-acting alarmin cytokine that can drive inflammatory
responses following tissue damage or infection and is a promising target for treatment of …

The exposure of the airway epithelium to external stimuli such as allergens, microbes, and
air pollution triggers the release of the alarmin cytokines IL-25, IL-33 and thymic stromal …

Abstract The Suppression of Tumorigenicity 2 protein (ST2) is a member of the interleukin
(IL) 1 receptor family with transmembrane (ST2L) and soluble (sST2) isoforms that are (over) …

Systemic sclerosis (SSc) is an autoimmune disease with a poor prognosis. To date, the
pathogenesis of SSc is still unclear; moreover, its pathological conditions include …

IL-33, a member of the IL-1 family of cytokines, was originally described in 2005 as a
promoter of type 2 immune responses. However, recent evidence reveals a more complex …

Head and neck squamous cell carcinomas (HNSCCs) are aggressive diseases with a
dismal patient prognosis. Despite significant advances in treatment modalities, the five-year …

Acute organ injuries such as acute cerebrovascular accidents, myocardial infarction, acute
kidney injury, acute lung injury, and others are among the leading causes of death …

Background: Acute kidney injury (AKI) is a short-term life-threatening condition that, if
survived, can lead to renal insufficiency and development of chronic kidney disease. The …