Allosteric sodium in class A GPCR signaling

V Katritch, G Fenalti, EE Abola, BL Roth… - Trends in biochemical …, 2014 - cell.com
Despite their functional and structural diversity, G-protein-coupled receptors (GPCRs) share
a common mechanism of signal transduction via conformational changes in the seven …

International Union of Basic and Clinical Pharmacology. LXXXI. Nomenclature and classification of adenosine receptors—an update

BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2011 - ASPET
In the 10 years since our previous International Union of Basic and Clinical Pharmacology
report on the nomenclature and classification of adenosine receptors, no developments …

Structural basis for allosteric regulation of GPCRs by sodium ions

W Liu, E Chun, AA Thompson, P Chubukov, F Xu… - Science, 2012 - science.org
Pharmacological responses of G protein–coupled receptors (GPCRs) can be fine-tuned by
allosteric modulators. Structural studies of such effects have been limited due to the medium …

Receptors for purines and pyrimidines

V Ralevic, G Burnstock - Pharmacological reviews, 1998 - ASPET
Extracellular purines (adenosine, ADP, and ATP) and pyrimidines (UDP and UTP) are
important signaling molecules that mediate diverse biological effects via cellsurface …

International Union of Pharmacology. XXV. Nomenclature and classification of adenosine receptors

BB Fredholm, AP IJzerman, KA Jacobson… - Pharmacological …, 2001 - ASPET
Four adenosine receptors have been cloned and characterized from several mammalian
species. The receptors are named adenosine A1, A2A, A2B, and A3. The A2A and A2B …

The 2.1 Å Resolution Structure of Cyanopindolol-Bound β1-Adrenoceptor Identifies an Intramembrane Na+ Ion that Stabilises the Ligand-Free Receptor

JL Miller-Gallacher, R Nehme, T Warne, PC Edwards… - PloS one, 2014 - journals.plos.org
The β1-adrenoceptor (β1AR) is a G protein-coupled receptor (GPCR) that is activated by the
endogenous agonists adrenaline and noradrenaline. We have determined the structure of …

A chemogenomic analysis of the transmembrane binding cavity of human G‐protein‐coupled receptors

JS Surgand, J Rodrigo, E Kellenberger… - Proteins: Structure …, 2006 - Wiley Online Library
The amino acid sequences of 369 human nonolfactory G-protein-coupled receptors
(GPCRs) have been aligned at the seven transmembrane domain (TM) and used to extract …

Human Adenosine A2A Receptor: Molecular Mechanism of Ligand Binding and Activation

B Carpenter, G Lebon - Frontiers in pharmacology, 2017 - frontiersin.org
Adenosine receptors (ARs) comprise the P1 class of purinergic receptors and belong to the
largest family of integral membrane proteins in the human genome, the G protein-coupled …

The role of a sodium ion binding site in the allosteric modulation of the A2A adenosine G protein-coupled receptor

H Gutiérrez-de-Terán, A Massink, D Rodríguez, W Liu… - Structure, 2013 - cell.com
The function of G protein-coupled receptors (GPCRs) can be modulated by a number of
endogenous allosteric molecules. In this study, we used molecular dynamics, radioligand …

The role of receptor structure in determining adenosine receptor activity

ME Olah, GL Stiles - Pharmacology & therapeutics, 2000 - Elsevier
Adenosine produces a wide variety of physiological effects through the activation of cell
surface adenosine receptors (ARs). ARs are members of the G-protein-coupled receptor …