In situ self-assembly for cancer therapy and imaging

J Kim, S Lee, Y Kim, M Choi, I Lee, E Kim… - Nature Reviews …, 2023 - nature.com
In situ self-assembly—the in situ formation of complex materials via biochemical reactions of
monomers—has enhanced the efficacy of drug delivery for cancer therapy and imaging. So …

Enhancing the therapeutic efficacy of nanoparticles for cancer treatment using versatile targeted strategies

H Tian, T Zhang, S Qin, Z Huang, L Zhou, J Shi… - Journal of hematology & …, 2022 - Springer
Poor targeting of therapeutics leading to severe adverse effects on normal tissues is
considered one of the obstacles in cancer therapy. To help overcome this, nanoscale drug …

Engineering nanomedicine for glutathione depletion-augmented cancer therapy

Y Xiong, C Xiao, Z Li, X Yang - Chemical Society Reviews, 2021 - pubs.rsc.org
Glutathione (GSH), the main redox buffer, has long been recognized as a pivotal modulator
of tumor initiation, progression and metastasis. It is also implicated in the resistance of …

Tumor‐microenvironment‐responsive nanomedicine for enhanced cancer immunotherapy

S Peng, F Xiao, M Chen, H Gao - Advanced Science, 2022 - Wiley Online Library
The past decades have witnessed great progress in cancer immunotherapy, which has
profoundly revolutionized oncology, whereas low patient response rates and potential …

Antioxidant, antimicrobial and antiviral properties of herbal materials

S Parham, AZ Kharazi, HR Bakhsheshi-Rad, H Nur… - Antioxidants, 2020 - mdpi.com
Recently, increasing public concern about hygiene has been driving many studies to
investigate antimicrobial and antiviral agents. However, the use of any antimicrobial agents …

ROS in cancer therapy: the bright side of the moon

B Perillo, M Di Donato, A Pezone, E Di Zazzo… - … & molecular medicine, 2020 - nature.com
Reactive oxygen species (ROS) constitute a group of highly reactive molecules that have
evolved as regulators of important signaling pathways. It is now well accepted that moderate …

Aspects of the tumor microenvironment involved in immune resistance and drug resistance

K Khalaf, D Hana, JTT Chou, C Singh… - Frontiers in …, 2021 - frontiersin.org
The tumor microenvironment (TME) is a complex and ever-changing “rogue organ”
composed of its own blood supply, lymphatic and nervous systems, stroma, immune cells …

Reactive oxygen species (ROS) as pleiotropic physiological signalling agents

H Sies, DP Jones - Nature reviews Molecular cell biology, 2020 - nature.com
Abstract 'Reactive oxygen species'(ROS) is an umbrella term for an array of derivatives of
molecular oxygen that occur as a normal attribute of aerobic life. Elevated formation of the …

NAD+ metabolism, stemness, the immune response, and cancer

LE Navas, A Carnero - Signal transduction and targeted therapy, 2021 - nature.com
NAD+ was discovered during yeast fermentation, and since its discovery, its important roles
in redox metabolism, aging, and longevity, the immune system and DNA repair have been …

Cancer metabolism: phenotype, signaling and therapeutic targets

JH Park, WY Pyun, HW Park - Cells, 2020 - mdpi.com
Aberrant metabolism is a major hallmark of cancer. Abnormal cancer metabolism, such as
aerobic glycolysis and increased anabolic pathways, has important roles in tumorigenesis …