From therapeutic drug monitoring to model‐informed precision dosing for antibiotics
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
evolved as important tools to inform rational dosing of antibiotics in individual patients with …
Clinical practice guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing: a consensus review by the Japanese …
K Matsumoto, K Oda, K Shoji, Y Hanai, Y Takahashi… - Pharmaceutics, 2022 - mdpi.com
Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …
Model-informed precision dosing of antibiotics in pediatric patients: a narrative review
Optimal pharmacotherapy in pediatric patients with suspected infections requires
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …
A hybrid machine learning/pharmacokinetic approach outperforms maximum a posteriori Bayesian estimation by selectively flattening model priors
Abstract Model‐informed precision dosing (MIPD) approaches typically apply maximum a
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …
External evaluation of population pharmacokinetic models for precision dosing: current state and knowledge gaps
M El Hassani, A Marsot - Clinical Pharmacokinetics, 2023 - Springer
Predicting drug exposures using population pharmacokinetic models through Bayesian
forecasting software can improve individual pharmacokinetic/pharmacodynamic target …
forecasting software can improve individual pharmacokinetic/pharmacodynamic target …
Continuous learning in model‐informed precision dosing: a case study in pediatric dosing of vancomycin
Model‐informed precision dosing (MIPD) leverages pharmacokinetic (PK) models to tailor
dosing to an individual patient's needs, improving attainment of therapeutic drug exposure …
dosing to an individual patient's needs, improving attainment of therapeutic drug exposure …
Individualized patient care through model-informed precision dosing: reflections on training future practitioners
R Jelliffe, J Liu, GL Drusano, MN Martinez - The AAPS Journal, 2022 - Springer
Prior to his passing, Dr. Roger Jelliffe, expressed the need for educating future physicians
and clinical pharmacists on the availability of computer-based tools to support dose …
and clinical pharmacists on the availability of computer-based tools to support dose …
3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy: Are we there yet?
G Wyszogrodzka-Gaweł, O Shuklinova, B Lisowski… - Drug Discovery …, 2023 - Elsevier
Precision medicine requires selecting the appropriate dosage regimen for a patient using
the right drug, at the right time. Model-Informed Precision Dosing (MIPD) is a concept …
the right drug, at the right time. Model-Informed Precision Dosing (MIPD) is a concept …
Semi-automated therapeutic drug monitoring as a pillar toward personalized medicine for tuberculosis management
Standard tuberculosis (TB) management has failed to control the growing number of drug-
resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate …
resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate …
Clinical decision support for chemotherapy‐induced neutropenia using a hybrid pharmacodynamic/machine learning model
Consensus guidelines recommend use of granulocyte colony stimulating factor in patients
deemed at risk of chemotherapy‐induced neutropenia, however, these risk models are …
deemed at risk of chemotherapy‐induced neutropenia, however, these risk models are …