From therapeutic drug monitoring to model‐informed precision dosing for antibiotics

SG Wicha, AG Märtson, EI Nielsen… - Clinical …, 2021 - Wiley Online Library
Therapeutic drug monitoring (TDM) and model‐informed precision dosing (MIPD) have
evolved as important tools to inform rational dosing of antibiotics in individual patients with …

Clinical practice guidelines for therapeutic drug monitoring of vancomycin in the framework of model-informed precision dosing: a consensus review by the Japanese …

K Matsumoto, K Oda, K Shoji, Y Hanai, Y Takahashi… - Pharmaceutics, 2022 - mdpi.com
Background: To promote model-informed precision dosing (MIPD) for vancomycin (VCM),
we developed statements for therapeutic drug monitoring (TDM). Methods: Ten clinical …

Model-informed precision dosing of antibiotics in pediatric patients: a narrative review

A Abdulla, E Edwina, RB Flint, K Allegaert… - Frontiers in …, 2021 - frontiersin.org
Optimal pharmacotherapy in pediatric patients with suspected infections requires
understanding and integration of relevant data on the antibiotic, bacterial pathogen, and …

A hybrid machine learning/pharmacokinetic approach outperforms maximum a posteriori Bayesian estimation by selectively flattening model priors

JH Hughes, RJ Keizer - CPT: pharmacometrics & systems …, 2021 - Wiley Online Library
Abstract Model‐informed precision dosing (MIPD) approaches typically apply maximum a
posteriori (MAP) Bayesian estimation to determine individual pharmacokinetic (PK) …

External evaluation of population pharmacokinetic models for precision dosing: current state and knowledge gaps

M El Hassani, A Marsot - Clinical Pharmacokinetics, 2023 - Springer
Predicting drug exposures using population pharmacokinetic models through Bayesian
forecasting software can improve individual pharmacokinetic/pharmacodynamic target …

Continuous learning in model‐informed precision dosing: a case study in pediatric dosing of vancomycin

JH Hughes, DMH Tong, SS Lucas… - Clinical …, 2021 - Wiley Online Library
Model‐informed precision dosing (MIPD) leverages pharmacokinetic (PK) models to tailor
dosing to an individual patient's needs, improving attainment of therapeutic drug exposure …

Individualized patient care through model-informed precision dosing: reflections on training future practitioners

R Jelliffe, J Liu, GL Drusano, MN Martinez - The AAPS Journal, 2022 - Springer
Prior to his passing, Dr. Roger Jelliffe, expressed the need for educating future physicians
and clinical pharmacists on the availability of computer-based tools to support dose …

3D printing combined with biopredictive dissolution and PBPK/PD modeling optimization and personalization of pharmacotherapy: Are we there yet?

G Wyszogrodzka-Gaweł, O Shuklinova, B Lisowski… - Drug Discovery …, 2023 - Elsevier
Precision medicine requires selecting the appropriate dosage regimen for a patient using
the right drug, at the right time. Model-Informed Precision Dosing (MIPD) is a concept …

Semi-automated therapeutic drug monitoring as a pillar toward personalized medicine for tuberculosis management

RP Jayanti, NP Long, NK Phat, YS Cho, JG Shin - Pharmaceutics, 2022 - mdpi.com
Standard tuberculosis (TB) management has failed to control the growing number of drug-
resistant TB cases worldwide. Therefore, innovative approaches are required to eradicate …

Clinical decision support for chemotherapy‐induced neutropenia using a hybrid pharmacodynamic/machine learning model

JH Hughes, DMH Tong, V Burns, B Daly… - CPT …, 2023 - Wiley Online Library
Consensus guidelines recommend use of granulocyte colony stimulating factor in patients
deemed at risk of chemotherapy‐induced neutropenia, however, these risk models are …