Background Greater access to evidence-based psychological treatments is needed. This
review aimed to evaluate whether internet-delivered psychological treatments for mood and …

Background The acupoint selections impact the effects of acupuncture, and preliminary
evidence showed potential connection between pain threshold (PT) and acupuncture …

The concept of clinical equipoise restricts the use of placebo controls in clinical trials when
there already exists a proven effective treatment. Several critics of clinical equipoise have …

Despite the increasing recognition that heuristics may be involved in myriad scientific
activities, much about how to use them prudently remains obscure. As typically defined …

The explanatory/pragmatic-trial distinction enjoys a burgeoning philosophical and medical
literature and a significant contingent of support among philosophers and healthcare …

The emerging paradigm of precision medicine strives to leverage the tools of molecular
biology to prospectively tailor treatments to the individual patient. Fundamental to the …

John Worrall and Nancy Cartwright have both argued that randomized controlled trials
(RCTs) are “testing the wrong theory.” They claim that RCTs are designed to test inferences …

What makes a high-quality biomarker experiment? The success of personalized medicine
hinges on the answer to this question. In this paper, I argue that judgment about the quality …

It has been almost 20 years since the field of bioethics was galvanized by a controversial
series of multinational AZT trials employing placebo controls on pregnant HIV-positive …

As Isabelle Stengers points out, researchers often approach projects as if they were
puzzles,'a problem whose interest is conferred solely by the rules of the game'(Stengers …