The role of NLRP3 inflammasome in cerebrovascular diseases pathology and possible therapeutic targets
R Bai, Y Lang, J Shao, Y Deng, R Refuhati… - ASN neuro, 2021 - journals.sagepub.com
Cerebrovascular diseases are pathological conditions involving impaired blood flow in the
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …
brain, primarily including ischaemic stroke, intracranial haemorrhage, and subarachnoid …
Inflammasomes as biomarkers and therapeutic targets in traumatic brain injury and related-neurodegenerative diseases: A comprehensive overview
D Kattan, C Barsa, S Mekhijian, Z Shakkour… - Neuroscience & …, 2023 - Elsevier
Given the ambiguity surrounding traumatic brain injury (TBI) pathophysiology and the lack of
any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an …
any Food and Drug Administration (FDA)-approved neurotherapeutic drugs, there is an …
Chlorogenic acid exerts neuroprotective effect against hypoxia-ischemia brain injury in neonatal rats by activating Sirt1 to regulate the Nrf2-NF-κB signaling pathway
Y Zheng, L Li, B Chen, Y Fang, W Lin, T Zhang… - Cell Communication and …, 2022 - Springer
Background Neonatal hypoxic-ischemic brain injury (HIE) is caused by perinatal asphyxia,
which is associated with various confounding factors. Although studies on the pathogenesis …
which is associated with various confounding factors. Although studies on the pathogenesis …
Neferine protects against hypoxic‐ischemic brain damage in neonatal rats by suppressing NLRP3‐mediated inflammasome activation
J Zhu, B Yu, X Huang, M He, B Chen… - Oxidative Medicine …, 2021 - Wiley Online Library
Hypoxic‐ischemic encephalopathy (HIE) is recognized as the main cause of neonatal death,
and efficient treatment strategies remain limited. Given the prevalence of HIE and the …
and efficient treatment strategies remain limited. Given the prevalence of HIE and the …
Downregulated miR-451a as a feature of the plasma cfRNA landscape reveals regulatory networks of IL-6/IL-6R-associated cytokine storms in COVID-19 patients
Rapidly spreading coronavirus disease 2019 (COVID-19) is currently affecting the world.
Specifically, cytokine storms are a key feature in a substantial number of COVID-19 patients …
Specifically, cytokine storms are a key feature in a substantial number of COVID-19 patients …
[HTML][HTML] miR-374a-5p regulates inflammatory genes and monocyte function in patients with inflammatory bowel disease
C Perez-Sanchez, A Barbera Betancourt… - Journal of Experimental …, 2022 - rupress.org
Disclosures: PA Lyons reported personal fees from PredictImmune Ltd outside the submitted
work. LK Modis was an employee of GSK at the time of the work and is a current employee …
work. LK Modis was an employee of GSK at the time of the work and is a current employee …
NLRP3 Inflammasome's Activation in Acute and Chronic Brain Diseases—An Update on Pathogenetic Mechanisms and Therapeutic Perspectives with Respect to …
A Chiarini, L Gui, C Viviani, U Armato, I Dal Prà - Biomedicines, 2023 - mdpi.com
Increasingly prevalent acute and chronic human brain diseases are scourges for the elderly.
Besides the lack of therapies, these ailments share a neuroinflammation that is …
Besides the lack of therapies, these ailments share a neuroinflammation that is …
Epigenetic regulations of microglia/macrophage polarization in ischemic stroke
M Qiu, E Xu, L Zhan - Frontiers in Molecular Neuroscience, 2021 - frontiersin.org
Ischemic stroke is one of the leading causes of death and disability worldwide. Microglia/
macrophages (MMs)-mediated neuroinflammation contributes significantly to the …
macrophages (MMs)-mediated neuroinflammation contributes significantly to the …
[HTML][HTML] MicroRNA-146a-5p alleviates lipopolysaccharide-induced NLRP3 inflammasome injury and pro-inflammatory cytokine production via the regulation of TRAF6 …
J Hou, Q Deng, X Deng, W Zhong, S Liu… - Annals of Translational …, 2021 - ncbi.nlm.nih.gov
Background Microribonucleic acids (miRNAs) have an evident role in regulating endothelial
inflammation and dysfunction, which characterizes the early stages of atherosclerosis. The …
inflammation and dysfunction, which characterizes the early stages of atherosclerosis. The …
[HTML][HTML] Modulation of Inflammatory Response by Electromagnetic Field Stimulation in Traumatic Brain Injury in Yucatan Swine
Y Mendoza-Mari, V Rai, MM Radwan… - Journal of surgery …, 2024 - ncbi.nlm.nih.gov
Traumatic brain injury is a leading cause of disability and death worldwide and represents a
high economic burden for families and national health systems. After mechanical impact to …
high economic burden for families and national health systems. After mechanical impact to …