Epidemiological data from the Center of Disease Control (CDC) and the World Health
Organization (WHO) statistics in 2017 show that 10.0 million people around the world …

One of the main features of the immune response to M. Tuberculosis is the formation of an
organized structure called granuloma. It consists mainly in the recruitment at the infectious …

Therapeutic intravesical instillation of bacillus Calmette-Guérin (BCG) is effective at
triggering inflammation and eliciting successful tumor immunity in patients with non–muscle …

Lack of access to human tissues with untreated tuberculosis (TB) has forced generations of
researchers to use animal models and to adopt a paradigm that granulomas are the …

A major challenge in tuberculosis (TB) is to improve current vaccination and therapeutic
strategies and this requires a fine understanding of the mechanisms that mediate protection …

Following infection with Mycobacterium tuberculosis, the causative agent of tuberculosis
(TB), most human hosts are able to contain the infection and avoid progression to active TB …

As a fundamental intracellular catabolic process, autophagy is important and required for the
elimination of protein aggregates and damaged cytosolic organelles during a variety of …

Studies over the past decade have helped to decipher molecular networks dependent on
Toll-like receptor (TLR) signaling, in mycobacteria-infected macrophages. Stimulation of …

Tuberculosis, caused by Mycobacterium tuberculosis infection, is a major cause of morbidity
and mortality in the world today. M. tuberculosis hijacks the phagosome-lysosome trafficking …

Bladder cancer is one of the leading causes of death worldwide. The main immune
mechanisms which lead to bladder cancer development or treatment outcomes have yet to …