Targeted therapeutics and novel signaling pathways in non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH)

X Xu, KL Poulsen, L Wu, S Liu, T Miyata… - Signal transduction and …, 2022 - nature.com
Non-alcohol-associated fatty liver/steatohepatitis (NAFL/NASH) has become the leading
cause of liver disease worldwide. NASH, an advanced form of NAFL, can be progressive …

NAFLD and cardiovascular diseases: a clinical review

P Kasper, A Martin, S Lang, F Kuetting… - Clinical research in …, 2021 - Springer
Non-alcoholic fatty liver DISEASE (NAFLD) is the most common chronic liver disease in
Western countries and affects approximately 25% of the adult population. Since NAFLD is …

Pathophysiological molecular mechanisms of obesity: a link between MAFLD and NASH with cardiovascular diseases

J Gutiérrez-Cuevas, A Santos… - International Journal of …, 2021 - mdpi.com
Obesity is now a worldwide epidemic ensuing an increase in comorbidities' prevalence,
such as insulin resistance, type 2 diabetes (T2D), metabolic dysfunction-associated fatty …

Host-microbiome interactions: Gut-Liver axis and its connection with other organs

S Anand, SS Mande - npj Biofilms and Microbiomes, 2022 - nature.com
An understanding of connections between gut microbiome and liver has provided important
insights into the pathophysiology of liver diseases. Since gut microbial dysbiosis increases …

Aging, oxidative stress and degenerative diseases: mechanisms, complications and emerging therapeutic strategies

MR Chaudhary, S Chaudhary, Y Sharma, TA Singh… - Biogerontology, 2023 - Springer
Aging accompanied by several age-related complications, is a multifaceted inevitable
biological progression involving various genetic, environmental, and lifestyle factors. The …

[HTML][HTML] Aspartate aminotransferase and cardiovascular disease—a narrative review

G Ndrepepa - Journal of Laboratory and Precision Medicine, 2021 - jlpm.amegroups.org
This narrative review summarized the existing knowledge on the association between
aspartate aminotransferase (AST) and cardiovascular disease (CVD). AST plays a key role …

[HTML][HTML] Pathophysiological mechanisms and clinical evidence of relationship between Nonalcoholic fatty liver disease (NAFLD) and cardiovascular disease

R Galiero, A Caturano, E Vetrano, A Cesaro… - Reviews in …, 2021 - imrpress.com
Evidence suggests a close connection between Nonalcoholic Fatty Liver Disease (NAFLD)
and increased cardiovascular (CV) risk. Several cross-sectional studies report that NAFLD is …

The role of resveratrol in liver disease: A comprehensive review from in vitro to clinical trials

C Izzo, M Annunziata, G Melara, R Sciorio, M Dallio… - Nutrients, 2021 - mdpi.com
Many studies have shown that resveratrol has a lot of therapeutic effects on liver disorders.
Its administration can significantly increase the survival rate after liver transplantation …

Multi-organ imaging demonstrates the heart-brain-liver axis in UK Biobank participants

C McCracken, Z Raisi-Estabragh, M Veldsman… - Nature …, 2022 - nature.com
Medical imaging provides numerous insights into the subclinical changes that precede
serious diseases such as heart disease and dementia. However, most imaging research …

Metabolic dysfunction-associated fatty liver disease and cardiovascular disease: a meta-analysis

W Wen, H Li, C Wang, C Chen, J Tang… - Frontiers in …, 2022 - frontiersin.org
Background Metabolic dysfunction-associated fatty liver disease [MAFLD, formerly known as
nonalcoholic fatty liver disease (NAFLD)] is one of the most important causes of liver disease …