Objective Use of the frailty index to measure an accumulation of deficits has been proven a
valuable method for identifying elderly people at risk for increased vulnerability, disease …

Liver fibrosis and in particular cirrhosis are the major causes of morbidity and mortality of
patients with chronic liver disease. Their prevention or reversal have become major …

Transglutaminase 2 (TG2) is a ubiquitously expressed enzyme catalyzing the crosslinking
between Gln and Lys residues and involved in various pathophysiological events. Besides …

Summary Transglutaminase type 2 (TG2) is a multifunctional enzyme that plays a key role in
mitochondria homeostasis under stressful cellular conditions. TG2 interactome analysis …

Cells communicate with their environment via surface proteins and secreted factors.
Unconventional protein secretion (UPS) is an evolutionarily conserved process, via which …

The extracellular matrix (ECM) is a diverse microenvironment that maintains bidirectional
communication with surrounding cells to regulate cell and tissue homeostasis. The classical …

Acute kidney injury (AKI) represents a common complication in critically ill patients that is
associated with increased morbidity and mortality. In a murine AKI model induced by …

The biocatalytic activity of transglutaminases (TGs) leads to the synthesis of new covalent
isopeptide bonds (crosslinks) between peptide-bound glutamine and lysine residues, but …

Molecular markers for predicting prognosis of colorectal cancer (CRC) patients are urgently
needed for effective disease management. We reported previously that the multifunctional …

Functional group modification is one of the main strategies used in drug discovery and
development. Despite the controversy of being identified for many years as a biologically …