Combining diverse experimental structural and interactomic methods allows for the
construction of comprehensible molecular encyclopedias of biological systems. Typically …

Presentation of antigens by human leukocyte antigen (HLA) complexes at the cell surface is
a key process in the immune response. The α-chain, containing the peptide-binding groove …

Chemical cross‐linking mass spectrometry (CXMS) has emerged as a powerful technology
to analyze protein complexes. However, the progress of in vivo CXMS studies has been …

Extracellular vesicles (EVs) are blood‐borne messengers that coordinate signalling
between different tissues and organs in the body. The specificity of such crosstalk is …

Through the presentation of peptide antigens to cytotoxic T lymphocytes, major
histocompatibility complex (MHC) class I molecules mediate the adaptive immune response …

At the plasma membrane of mammalian cells, major histocompatibility complex class I
molecules (MHC-I) present antigenic peptides to cytotoxic T cells. Following the loss of the …

Peptide presentation by MHC class I and MHC class II molecules plays important roles in the
regulation of the immune response. One factor in these displays is the density of antigen …

Alloantibody recognition of donor human leukocyte antigen (HLA) is associated with poor
clinical transplantation outcomes. However, the molecular and structural basis for the …

Extracellular Vesicles (EVs) are naturally secreted nanoparticles with a plethora of functions
in the human body and remarkable potential as diagnostic and therapeutic tools. Starting …

Background: Cross-linking mass spectrometry (XL-MS) is a powerful technology capable of
yielding structural insights across the complex cellular protein interaction network. However …