[HTML][HTML] Impact of oxysterols on cell death, proliferation, and differentiation induction: current status

FA de Freitas, D Levy, A Zarrouk, G Lizard… - Cells, 2021 - mdpi.com
Oxysterols are oxidized derivatives of cholesterol produced by enzymatic activity or non-
enzymatic pathways (auto-oxidation). The oxidation processes lead to the synthesis of about …

[HTML][HTML] Effects of oxysterols on immune cells and related diseases

FA de Freitas, D Levy, CO Reichert, E Cunha-Neto… - Cells, 2022 - mdpi.com
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …

Screening for liver X receptor modulators: Where are we and for what use?

J Buñay, A Fouache, A Trousson… - British Journal of …, 2021 - Wiley Online Library
Liver X receptors (LXRs) are members of the nuclear receptor superfamily that are
canonically activated by oxidized derivatives of cholesterol. Since the mid‐90s, numerous …

Hormone-sensitive lipase deficiency affects the expression of SR-BI, LDLr, and ABCA1 receptors/transporters involved in cellular cholesterol uptake and efflux and …

ME Casado, L Huerta, A Marcos-Díaz, AI Ortiz… - … et Biophysica Acta (BBA …, 2021 - Elsevier
Hormone-sensitive lipase (HSL) hydrolyse acylglycerols, cholesteryl and retinyl esters. HSL
is a key lipase in mice testis, as HSL deficiency results in male sterility. The present work …

[HTML][HTML] Pharmacogenetic association of the NR1H3 promoter variant with antihypertensive response among patients with hypertension: A longitudinal study

Y Chen, Y Han, Y Wu, R Hui, Y Yang… - Frontiers in …, 2023 - frontiersin.org
Background: The genetic factors in assessing therapeutic efficacy and predicting
antihypertensive drug response are unclear. Therefore, this study aims to identify the …

[HTML][HTML] Understanding the underlying molecular mechanisms of meiotic arrest during in vitro spermatogenesis in rat prepubertal testicular tissue

J Saulnier, F Chalmel, M Delessard, L Moutard… - International Journal of …, 2022 - mdpi.com
In vitro spermatogenesis appears to be a promising approach to restore the fertility of
childhood cancer survivors. The rat model has proven to be challenging, since germ cell …

[HTML][HTML] The construction of a testis transcriptional cell atlas from embryo to adult reveals various somatic cells and their molecular roles

N Salehi, M Totonchi - Journal of Translational Medicine, 2023 - Springer
Background The testis is a complex organ that undergoes extensive developmental
changes from the embryonic stage to adulthood. The development of germ cells, which give …

FXRα modulates leydig cell endocrine function in mouse

H Holota, L Thirouard, M Monrose, M Garcia… - Molecular and Cellular …, 2020 - Elsevier
The hypothalamic-pituitary axis exert a major control over endocrine and exocrine testicular
functions. The hypothalamic-pituitary axis corresponds to a cascade with the Gonadotropin …

Activation of liver X receptors ameliorates alterations in testicular function in rats exposed to electromagnetic radiation

NM Mahmoud, RS Gomaa, AE Salem - Alexandria Journal of Medicine, 2021 - ajol.info
Introduction: Cell phones are essential for modern life and their usage becomes prevalent.
Worries have increased concerning the harmful effects of their radio-frequency …

[PDF][PDF] Effects of Oxysterols on Immune Cells and Related Diseases. Cells 2022, 11, 1251

FA de Freitas, D Levy, CO Reichert, E Cunha-Neto… - 2022 - academia.edu
Oxysterols are the products of cholesterol oxidation. They have a wide range of effects on
several cells, organs, and systems in the body. Oxysterols also have an influence on the …