Telomeres are specialized nucleoprotein structures at the ends of linear chromosomes that
prevent the activation of DNA damage response and repair pathways. Numerous factors …

With the aging of the global population, accumulating interest is focused on manipulating the
fundamental aging‐related signaling pathways to delay the physiological aging process and …

Posttranscriptional modifications of mRNA have emerged as regulators of gene expression.
Although pseudouridylation is the most abundant, its biological role remains poorly …

Background & aims Monogenic forms of inflammatory bowel disease (IBD) illustrate the
essential roles of individual genes in pathways and networks safeguarding immune …

Intrahepatic cholangiocarcinoma (ICC) is a deadly cancer with rapid tumor progression.
While hyperactive mRNA translation caused by mis-regulated mRNA or tRNA modifications …

The uridine modifications pseudouridine (Ψ), dihydrouridine, and 5-methyluridine are
present in eukaryotic mRNAs. Many uridine-modifying enzymes are associated with human …

Currently, for seemingly every type of cancer, dysregulated levels of non-coding RNAs
(ncRNAs) are reported and non-coding transcripts are expected to be the next class of …

Telomeres are composed of repetitive DNA sequences that are replenished by the enzyme
telomerase to maintain the self-renewal capacity of stem cells. The RNA component of …

Small-molecule glycosides that exhibit a β-d-ribosyl residue linked to an aglycone via a
noncanonical C-glycosidic linkage are of great biological importance. They occur naturally …

FUS is a multifunctional protein involved in many aspects of RNA metabolism, including
transcription, splicing, translation, miRNA processing, and replication-dependent histone …