Altered B cell signalling in autoimmunity
DJ Rawlings, G Metzler, M Wray-Dutra… - Nature reviews …, 2017 - nature.com
Recent work has provided new insights into how altered B cell-intrinsic signals—through the
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …
B cell receptor (BCR) and key co-receptors—function together to promote the pathogenesis …
Spontaneous germinal centers and autoimmunity
PP Domeier, SL Schell, ZSM Rahman - Autoimmunity, 2017 - Taylor & Francis
Germinal centers (GCs) are dynamic microenvironments that form in the secondary
lymphoid organs and generate somatically mutated high-affinity antibodies necessary to …
lymphoid organs and generate somatically mutated high-affinity antibodies necessary to …
Akkermansia muciniphila and Lactobacillus plantarum ameliorate systemic lupus erythematosus by possibly regulating immune response and remodeling gut …
M Guo, M Lu, K Chen, R Xu, Y Xia, X Liu, Z Liu, Q Liu - Msphere, 2023 - Am Soc Microbiol
Systemic lupus erythematosus (SLE), characterized by persistent inflammation, is a complex
autoimmune disorder that affects all organs, challenging clinical treatment. Dysbiosis of gut …
autoimmune disorder that affects all organs, challenging clinical treatment. Dysbiosis of gut …
Type II but not type I IFN signaling is indispensable for TLR7-promoted development of autoreactive B cells and systemic autoimmunity
SB Chodisetti, AJ Fike, PP Domeier… - The Journal of …, 2020 - journals.aai.org
TLR7 is associated with development of systemic lupus erythematosus (SLE), but the
underlying mechanisms are incompletely understood. Although TLRs are known to activate …
underlying mechanisms are incompletely understood. Although TLRs are known to activate …
The complex association of FcγRIIb with autoimmune susceptibility
JS Verbeek, S Hirose, H Nishimura - Frontiers in Immunology, 2019 - frontiersin.org
FcγRIIb is the only inhibitory Fc receptor and controls many aspects of immune and
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …
inflammatory responses. The observation 19 years ago that Fc γ RIIb−/− mice generated by …
Self-DNA at the epicenter of SLE: immunogenic forms, regulation, and effects
C Soni, B Reizis - Frontiers in Immunology, 2019 - frontiersin.org
Self-reactive B cells generated through V (D) J recombination in the bone marrow or through
accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to …
accrual of random mutations in secondary lymphoid tissues are mostly purged or edited to …
[HTML][HTML] Research advances of vasoactive intestinal peptide in the pathogenesis of ulcerative colitis by regulating interleukin-10 expression in regulatory B cells
X Sun, Y Huang, YL Zhang, D Qiao… - World Journal of …, 2020 - ncbi.nlm.nih.gov
Ulcerative colitis (UC) is a chronic relapsed intestinal disease with an increasing incidence
around the world. The pathophysiology of UC remains unclear. However, the role of the …
around the world. The pathophysiology of UC remains unclear. However, the role of the …
The post-GWAS era: how to validate the contribution of gene variants in lupus
AJ Fike, I Elcheva, ZSM Rahman - Current rheumatology reports, 2019 - Springer
Abstract Purpose of Review Systemic lupus erythematosus (SLE) is a complex autoimmune
disease with strong genetic associations. Here, we provide an update on recent …
disease with strong genetic associations. Here, we provide an update on recent …
Germinal centers and autoimmune disease in humans and mice
AL DeFranco - Immunology and cell biology, 2016 - Wiley Online Library
Antibodies are involved in the pathogenesis of many autoimmune diseases. Although the
mechanisms underlying the antibody response to infection or vaccination are reasonably …
mechanisms underlying the antibody response to infection or vaccination are reasonably …
The STING inhibitor (ISD-017) reduces glomerulonephritis in 129.B6.Fcgr2b-deficient mice
I Alee, P Chantawichitwong, A Leelahavanichkul… - Scientific Reports, 2024 - nature.com
The absence of stimulator of interferon genes (STING) in 129. B6. Fcgr2b-deficient mice
rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young …
rescue lupus phenotypes. The administration of a STING inhibitor (ISD017) into the young …