Considered as the second deadliest disease globally, cancer has captured the attention of
researchers who have been trying with perseverance to decode its hidden aspects, to find …

Microtubules (MTs), highly dynamic structures composed of α-and β-tubulin heterodimers,
are involved in cell movement and intracellular traffic and are essential for cell division …

Despite recent developments in diagnosis and treatment options, cancer remains one of the
most critical threats to health. Several anti-cancer therapies have been identified, but further …

Berberine alkaloids belong to the class of isoquinoline alkaloids that have been shown to
possess anticancer potential, berberine exhibits inhibitory effects on breast cancer …

In breast cancer (BC), STAT3 is hyperactivated. This study explored the design of
imidazopyridine-tethered pyrazolines as a de novo drug strategy for inhibiting STAT3 …

Microtubules are pivotal in diverse cellular functions encompassing cell signaling,
morphology, intracellular trafficking, and cell mitosis/division. They are validated targets for …

Background The use of certain chemotherapy agents is associated with the development of
a condition called “chemotherapy-associated neutropenic enterocolitis”(CANE). Objective …

The cornerstone for endometrial cancer treatment is an extrafascial removal of the uterus
with bilateral salpingo oophorectomy. 1 Metastatic disease in pelvic lymph nodes is the …

Anticancer drugs are one of the most direct means of cancer therapy. However, the various
cancer progressions hamper the development and discovery of anticancer drugs. In fact, the …

Background Cancer cell aggregation is a key process involved in the formation of tumor cell
clusters. It has recently been shown that clusters of circulating tumor cells (CTCs) have an …