Publisher Summary Celiac disease is an immune-mediated enteropathy triggered by the
ingestion of gluten in genetically susceptible individuals. The major predisposing genes are …

Genomic studies conducted on ancient individuals across Europe have revealed how
migrations have contributed to its present genetic landscape, but the territory of present-day …

Cardiovascular diseases are leading causes for death worldwide. Genetic disposition jointly
with traditional risk factors precipitates their manifestation. Whereas the implications of a …

Measurements of erythrocytes within the blood are important clinical traits and can indicate
various hematological disorders. We report here genome-wide association studies (GWAS) …

Celiac disease (CD) is a chronic enteropathy induced by dietary gluten in genetically
predisposed people. The keystone of CD pathogenesis is an adaptive immune response …

Finely tuned mechanisms enable the gastrointestinal tract to break down dietary
components into nutrients without mounting, in the majority of cases, a dysregulated immune …

Background Celiac disease is classically manifested in the gastrointestinal (GI) tract but
extraintestinal symptoms, such as dermatitis herpetiformis (DH), are also common. Besides …

To discover new rheumatoid arthritis (RA) risk loci, we systematically examined 370 SNPs
from 179 independent loci with P< 0.001 in a published meta-analysis of RA genome-wide …

The etiology of autoimmune diseases is due to a combination of genetic predisposition and
environmental factors that alter the expression of immune regulatory genes through various …

After more than a decade of hope and hype, researchers are finally making inroads into
understanding the genetic basis of many common human diseases. The use of genome …