[HTML][HTML] The role of ubiquitination and deubiquitination in cancer metabolism

T Sun, Z Liu, Q Yang - Molecular cancer, 2020 - Springer
Metabolic reprogramming, including enhanced biosynthesis of macromolecules, altered
energy metabolism, and maintenance of redox homeostasis, is considered a hallmark of …

[HTML][HTML] Strategies of macrophages to maintain bone homeostasis and promote bone repair: a narrative review

Y Hu, J Huang, C Chen, Y Wang, Z Hao… - Journal of Functional …, 2022 - mdpi.com
Bone homeostasis (a healthy bone mass) is regulated by maintaining a delicate balance
between bone resorption and bone formation. The regulation of physiological bone …

[HTML][HTML] Quercetin alleviates ferroptosis accompanied by reducing M1 macrophage polarization during neutrophilic airway inflammation

Y Wang, R Wan, W Peng, X Zhao, W Bai… - European journal of …, 2023 - Elsevier
Ferroptosis is a kind of regulated cell death, supporting the pathological process of lung
inflammation, including asthma. Quercetin (QCT), a kind of natural dietary flavonoid, exerts …

IL-24 deficiency protects mice against bleomycin-induced pulmonary fibrosis by repressing IL-4-induced M2 program in macrophages

LZ Rao, Y Wang, L Zhang, G Wu, L Zhang… - Cell Death & …, 2021 - nature.com
Idiopathic pulmonary fibrosis (IPF) is the most common type of idiopathic interstitial
pneumonia and has one of the poorest prognosis. However, the molecular mechanisms …

[HTML][HTML] Epigenetic regulation of SMAD3 by histone methyltransferase SMYD2 promotes lung cancer metastasis

K Kim, TY Ryu, E Jung, TS Han, J Lee, SK Kim… - … & Molecular Medicine, 2023 - nature.com
Epigenetic alterations, especially histone methylation, are key factors in cell migration and
invasion in cancer metastasis. However, in lung cancer metastasis, the mechanism by which …

[HTML][HTML] Tartrate-resistant acid phosphatase 5 promotes pulmonary fibrosis by modulating β-catenin signaling

Y Hu, Q Wang, J Yu, Q Zhou, Y Deng, J Liu… - Nature …, 2022 - nature.com
Idiopathic pulmonary fibrosis (IPF) is a fatal interstitial lung disease with limited therapeutic
options. Tartrate-resistant acid phosphatase 5 (ACP5) performs a variety of functions …

[HTML][HTML] Local administration of liposomal-based Srpx2 gene therapy reverses pulmonary fibrosis by blockading fibroblast-to-myofibroblast transition

Q Wang, J Liu, Y Hu, T Pan, Y Xu, J Yu, W Xiong… - Theranostics, 2021 - ncbi.nlm.nih.gov
Idiopathic pulmonary fibrosis (IPF) is a chronic and progressive fatal interstitial lung disease
characterized by abnormal transition and proliferation of fibroblasts. The uncontrolled …

The methyl-CpG-binding domain 2 facilitates pulmonary fibrosis by orchestrating fibroblast to myofibroblast differentiation

Y Wang, L Zhang, T Huang, GR Wu… - European …, 2022 - Eur Respiratory Soc
Although DNA methylation has been recognised in the pathogenesis of idiopathic
pulmonary fibrosis (IPF), the exact mechanisms are yet to be fully addressed. Herein, we …

Scutellarein inhibits BLM-mediated pulmonary fibrosis by affecting fibroblast differentiation, proliferation, and apoptosis

K Miao, T Pan, Y Mou, L Zhang… - … in Chronic Disease, 2020 - journals.sagepub.com
Introduction: Idiopathic pulmonary fibrosis (IPF) is a progressive and irreversible interstitial
pulmonary disease that has a poor prognosis. Scutellarein, which is extracted from the …

Macrophage‐targeted delivery of siRNA to silence Mecp2 gene expression attenuates pulmonary fibrosis

Y Mou, GR Wu, Q Wang, T Pan, L Zhang… - Bioengineering & …, 2022 - Wiley Online Library
Idiopathic pulmonary fibrosis (IPF) is a progressive interstitial lung disease characterized by
the infiltration of macrophages in the fibrotic region. Currently, no therapeutic strategies …