Disorders of cell number that result from an imbalance between the death of parenchymal
cells and the proliferation or recruitment of maladaptive cells contributes to the pathogenesis …

In recent years, the incidence of gastrointestinal cancers is increasing, particularly in the
younger population. Effective treatment is crucial for improving patients' survival outcomes …

Acute kidney injury (AKI) is not only a worldwide problem with a cruel hospital mortality rate
but also an independent risk factor for chronic kidney disease and a promoting factor for its …

Given the rapidly aging population, aging-related diseases are becoming an excessive
burden on the global healthcare system. Metformin has been shown to be beneficial to many …

Necroptosis, a pathway of regulated necrosis, involves recruitment and activation of RIPK1,
RIPK3 and MLKL, leading to cell membrane rupture, cell death and release of intracellular …

Necroptosis is a mode of programmed, lytic cell death that is executed by the mixed lineage
kinase domain-like (MLKL) pseudokinase following activation by the upstream kinases …

Inflammation is a key characteristic of both acute and chronic kidney diseases. Preclinical
data suggest the involvement of the NLRP3/Inflammasome, receptor-interacting protein …

Necroptosis, a programmed cell death mechanism distinct from apoptosis, has garnered
attention for its role in various pathological conditions. While initially recognized for its …

The necroptosis pathway is a lytic, pro-inflammatory mode of cell death that is widely
implicated in human disease, including renal, pulmonary, gut and skin inflammatory …

Renal ischemia‒reperfusion injury (IRI) is one of the main causes of acute kidney injury
(AKI), which is a potentially life-threatening condition with a high mortality rate. IRI is a …