Iron is a critical element for living cells in terrestrial life. Although iron metabolism is strictly
controlled in the body, disturbance of iron homeostasis under certain type of condition leads …

Macrophage immunotherapy is an emerging treatment strategy that modulates the immune
system to promote wound healing. The functionality and regeneration of tissue depend on …

Bone regeneration is a highly synchronized process that requires multiple biochemical,
bioelectrical, mechanical, and other physiological cues. The restoration and delivery of …

MicroRNAs (miRs) play an important role in regulating gene expression. Limited by their
instabilities, miR therapeutics require delivery vehicles. Tetrahedral framework nucleic acids …

Recent evidence highlights multifaceted biological needs to recapitulate the bone
microenvironment for bone regeneration. Neurotization has great potential for realizing multi …

Precise timing of macrophage polarization plays a pivotal role in immunomodulation of
tissue regeneration, yet most studies mainly focus on M2 macrophages for their anti …

The immune response of the host towards foreign body, especially in the form of giant cell
reaction against the implanted materials, is a vital factor for determining the repair outcome …

Small intestinal submucosa (SIS) hydrogel is a potential candidate for wound dressing since
its excellent biocompatibility and bioactivities. However, the intrinsic lack of sufficient …

The bone immune microenvironment (BIM) regulates bone regeneration and affects the
prognosis of fractures. However, there is currently no effective strategy that can precisely …

Periodontitis is a widespread oral disease characterized by continuous inflammation of the
periodontal tissue and an irreversible alveolar bone loss, which eventually leads to tooth …