Recent molecular studies have expanded the biological contexts in which topoisomerase II
(TOP2) has crucial functions, including DNA replication, transcription and chromosome …

This review covers mainly the past 25 years of research on the biological activities of lupeol,
a significant lupane-type triterpene represented in the plant, fungi and animal kingdoms …

Topoisomerase II is an essential enzyme that is required for virtually every process that
requires movement of DNA within the nucleus or the opening of the double helix. This …

Etoposide is an important chemotherapeutic agent that is used to treat a wide spectrum of
human cancers. It has been in clinical use for more than two decades and remains one of …

Type II topoisomerases are ubiquitous enzymes that play essential roles in a number of
fundamental DNA processes. They regulate DNA under-and overwinding, and resolve knots …

Topoisomerase 11 is an essential enzyme that plays a role in virtually every cellular DNA
process. This enzyme interconverts different topological forms of DNA by passing one …

Camptothecin analogues and derivatives appear to exert their antitumour activity by binding
to topoisomerase I and have shown significant activity against a broad range of tumours. In …

The purpose of this review article is to discuss established molecular mechanisms of
apoptosis and their relevance to cell death induced by environmental toxicants. Apoptosis is …

DNA damage induced by the cancer chemotherapeutic drug etoposide triggers the onset of
a series of intracellular events characteristic of apoptosis. Among the early changes …

Due to the dominating roles that caspases play in the apoptotic cascade, their activities
appear to be a primary factor in the death pathway (apoptosis versus oncosis/necrosis) …