[HTML][HTML] Pathogenesis of the Pseudomonas aeruginosa Biofilm: A Review

FF Tuon, LR Dantas, PH Suss, VS Tasca Ribeiro - Pathogens, 2022 - mdpi.com
Pseudomonas aeruginosa is associated with several human infections, mainly related to
healthcare services. In the hospital, it is associated with resistance to several antibiotics …

Antibiofilm activity of host defence peptides: Complexity provides opportunities

REW Hancock, MA Alford, EF Haney - Nature Reviews Microbiology, 2021 - nature.com
Host defence peptides (HDPs) are integral components of innate immunity across all living
organisms. These peptides can exert direct antibacterial effects, targeting planktonic cells …

[HTML][HTML] Mechanisms of action for antimicrobial peptides with antibacterial and antibiofilm functions

N Raheem, SK Straus - Frontiers in microbiology, 2019 - frontiersin.org
The antibiotic crisis has led to a pressing need for alternatives such as antimicrobial
peptides (AMPs). Recent work has shown that these molecules have great potential not only …

Peptidomimetic polyurethanes inhibit bacterial biofilm formation and disrupt surface established biofilms

A Vishwakarma, F Dang, A Ferrell… - Journal of the …, 2021 - ACS Publications
Over 80% of all chronic bacterial infections in humans are associated with biofilms, which
are surface-associated bacterial communities encased within a secreted exopolysaccharide …

Combating implant infections: shifting focus from bacteria to host

S Amin Yavari, SM Castenmiller… - Advanced …, 2020 - Wiley Online Library
The widespread use of biomaterials to support or replace body parts is increasingly
threatened by the risk of implant‐associated infections. In the quest for finding novel anti …

[HTML][HTML] Reassessing the host defense peptide landscape

EF Haney, SK Straus, REW Hancock - Frontiers in chemistry, 2019 - frontiersin.org
Current research has demonstrated that small cationic amphipathic peptides have strong
potential not only as antimicrobials, but also as antibiofilm agents, immune modulators, and …

Antimicrobial hydrogels: promising materials for medical application

K Yang, Q Han, B Chen, Y Zheng, K Zhang… - International Journal …, 2018 - Taylor & Francis
The rapid emergence of antibiotic resistance in pathogenic microbes is becoming an
imminent global public health problem. Local application of antibiotics might be a solution. In …

Pseudomonas aeruginosa Biofilms: Host Response and Clinical Implications in Lung Infections

NM Maurice, B Bedi, RT Sadikot - American journal of respiratory …, 2018 - atsjournals.org
Pseudomonas aeruginosa is a major health challenge that causes recalcitrant multidrug-
resistant infections, especially in immunocompromised and hospitalized patients. P …

[HTML][HTML] Approaches for the inhibition and elimination of microbial biofilms using macromolecular agents

LD Blackman, Y Qu, P Cass, KES Locock - Chemical Society Reviews, 2021 - pubs.rsc.org
Biofilms are complex three-dimensional structures formed at interfaces by the vast majority
of bacteria and fungi. These robust communities have an important detrimental impact on a …

An overview of antimicrobial peptides and the latest advances in their development

JM Sierra, E Fusté, F Rabanal, T Vinuesa… - Expert opinion on …, 2017 - Taylor & Francis
Introduction: The recent dramatic increase in the incidence of antimicrobial resistance has
been recognized by organizations such as the United Nations and World Health …