Writing and reading H2B monoubiquitylation
Monoubiquitylation of histone H2B (H2Bub1), catalyzed by the heterodimeric ubiquitin
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …
ligase complex RNF20/40, regulates multiple molecular and biological processes. The …
Histone H2B ubiquitin ligase RNF20 is required for MLL-rearranged leukemia
Mixed-lineage leukemia (MLL) fusions are potent oncogenes that initiate aggressive forms
of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene …
of acute leukemia. As aberrant transcriptional regulators, MLL-fusion proteins alter gene …
[HTML][HTML] The emerging role of deubiquitinating enzymes in genomic integrity, diseases, and therapeutics
M He, Z Zhou, AA Shah, H Zou, J Tao, Q Chen, Y Wan - Cell & bioscience, 2016 - Springer
The addition of mono-ubiquitin or poly-ubiquitin chain to signaling proteins in response to
DNA damage signal is thought to be a critical event that facilitates the recognition of DNA …
DNA damage signal is thought to be a critical event that facilitates the recognition of DNA …
[HTML][HTML] Histone H2B monoubiquitination: roles to play in human malignancy
AJ Cole, R Clifton-Bligh… - Endocrine-related cancer, 2015 - erc.bioscientifica.com
Ubiquitination has traditionally been viewed in the context of polyubiquitination that is
essential for marking proteins for degradation via the proteasome. Recent discoveries have …
essential for marking proteins for degradation via the proteasome. Recent discoveries have …
The histone methyltransferase Dot1/DOT1L as a critical regulator of the cell cycle
W Kim, M Choi, JE Kim - Cell Cycle, 2014 - Taylor & Francis
Dot1/DOT1L catalyzes the methylation of histone H3 lysine 79 (H3K79), which regulates
diverse cellular processes, such as development, reprogramming, differentiation, and …
diverse cellular processes, such as development, reprogramming, differentiation, and …
Mechanisms of genome instability induced by RNA-processing defects
The role of normal transcription and RNA processing in maintaining genome integrity is
becoming increasingly appreciated in organisms ranging from bacteria to humans. Several …
becoming increasingly appreciated in organisms ranging from bacteria to humans. Several …
Mechanisms of gene regulation by histone degradation in adaptation of yeast: an overview of recent advances
Histones are important component of eukaryotic cells chromatin and consist of arginine and
lysine residues. Histones play an important role in the protection of DNA. Their contents …
lysine residues. Histones play an important role in the protection of DNA. Their contents …
[HTML][HTML] Developing targeted therapies that exploit aberrant histone ubiquitination in cancer
LMP Jeusset, KJ McManus - Cells, 2019 - mdpi.com
Histone ubiquitination is a critical epigenetic mechanism regulating DNA-driven processes
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
such as gene transcription and DNA damage repair. Importantly, the cellular machinery …
[HTML][HTML] Testicular cancer from diagnosis to epigenetic factors
M Boccellino, D Vanacore, S Zappavigna… - Oncotarget, 2017 - ncbi.nlm.nih.gov
Testicular cancer (TC) is one of the most common neoplasms that occurs in male and
includes germ cell tumors (GCT), sex cord-gonadal stromal tumors and secondary testicular …
includes germ cell tumors (GCT), sex cord-gonadal stromal tumors and secondary testicular …
[HTML][HTML] Epigenetic modification and a role for the E3 ligase RNF40 in cancer development and metastasis
J Fu, L Liao, KS Balaji, C Wei, J Kim, J Peng - Oncogene, 2021 - nature.com
Abstract RNF40 (OMIM: 607700) is a really interesting new gene (RING) finger E3 ubiquitin
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …
ligase containing multiple coiled-coil domains and a C-terminal RING finger motif, which …