Oxidative stress damage is known as one of the important factors that induce neuropathic
pain (NP). Using antioxidant therapy usually achieves an obvious curative effect and …

Cholesterol is an essential component of plasma membrane and precursor of biological
active compounds, including hydroxycholesterols (HCs). HCs regulate cellular homeostasis …

Bone cancer pain (BCP) is an intractable clinical problem, and lacked effective drugs for
treating it. Recent research showed that several chemokines in the spinal cord are involved …

Painful diabetic neuropathy (PDN) is a severely debilitating chronic pain syndrome. Spinal
chemokine CXCL13 and its receptor CXCR5 were recently demonstrated to play a pivotal …

Chemokines and receptors have been implicated in the pathogenesis of chronic pain. Here,
we report that spinal nerve ligation (SNL) increased CXCR3 expression in dorsal root …

Background Calcitonin gene-related peptide (CGRP) as a mediator of microglial activation
at the transcriptional level may facilitate nociceptive signaling. Trimethylation of H3 lysine 27 …

Clinically, neuropathic pain treatment remains a challenging issue because the major
therapy, centred around pharmacological intervention, is not satisfactory enough to patient …

Background Peripheral nerve damage causes neuroinflammation, which plays a critical role
in establishing and maintaining neuropathic pain (NeP). The mechanisms contributing to …

Complex regional pain syndrome (CRPS) results in chronic and excruciating pain in
patients. Conventional therapies lack effectiveness, rendering it one of the most difficult to …

Despite recent progress regarding inexpensive medical approaches, many individuals suffer
from moderate to severe pain globally. The discovery and advent of exosomes, as biological …