The underlying mechanisms of neuropathic pain remain to be elucidated. Basic animal
research has suggested that lysophosphatidic acids, which are bioactive lipids produced by …

Spinal cord injury (SCI) is a devastating event with a tremendous impact in the life of the
affected individual and family. Traumatic injuries related to motor vehicle accidents, falls …

Neuropathic pain is a devastating disease that affects millions of people worldwide.
Serotonin (5-hydroxytryptamine, 5-HT) is involved in pain modulation. Several lines of …

Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism
of central sensitization is unclear. In this article, we further explore the presynaptic role of …

Complex regional pain syndrome (CRPS) results in chronic and excruciating pain in
patients. Conventional therapies lack effectiveness, rendering it one of the most difficult to …

Chemokines and their receptors participate in many biological processes, including the
modulation of neuroimmune interactions. Approximately fifty chemokines are distinguished …

Satellite glial cells (SGCs) play an important role in regulating the function of trigeminal
ganglion (TG) neurons. Multiple mediators are involved in the bidirectional communication …

Trigeminal nerve injury–induced neuropathic pain is a debilitating chronic orofacial pain
syndrome but lacks effective treatment. G protein–coupled receptors (GPCRs), especially …

Background Chemokine-mediated neuroinflammation plays an important role in the
pathogenesis of neuropathic pain. The chemokine CC motif ligand 7 (CCL7) and its receptor …

Highlights•Intrathecal injection DAPT suppressed Notch signaling and relieved vincristine-
induced neuropathic pain.•Inactivated Notch signaling could suppress microglial …