Central post-stroke pain (CPSP) is a highly refractory form of central neuropathic pain that
has been poorly studied mechanistically. Recent observations have emphasized the critical …

Previous studies have shown that CCL2 may cause chronic pain, but the exact mechanism
of central sensitization is unclear. In this article, we further explore the presynaptic role of …

Trigeminal nerve injury–induced neuropathic pain is a debilitating chronic orofacial pain
syndrome but lacks effective treatment. G protein–coupled receptors (GPCRs), especially …

Background and Purpose New remedies are required for the treatment of diabetic
neuropathic pain (DNP) due to insufficient efficacy of available therapies. Here, we used …

Highlights•Intrathecal injection DAPT suppressed Notch signaling and relieved vincristine-
induced neuropathic pain.•Inactivated Notch signaling could suppress microglial …

Satellite glial cells (SGCs) play an important role in regulating the function of trigeminal
ganglion (TG) neurons. Multiple mediators are involved in the bidirectional communication …

Background Neuropathic pain (NP) is the most prevalent form of chronic pain resulting from
nerve damage or injury. Despite the widespread use of Duhuo Jisheng decoction (DHJSD) …

Neuropathic pain, whose symptoms are characterized by spontaneous and irritation-
induced painful sensations, is a condition that poses a global burden. Numerous …

Epidural motor cortex stimulation (MCS) is an effective treatment for refractory neuropathic
pain; however, some individuals are unresponsive. In this study, we correlated the …

Background Astrocytes are highly glycolytic cells that play a crucial role in chronic pain.
Recently it has been found that inflammation and metabolism are related to the inflammatory …