XIAP, X-linked inhibitor of apoptosis protein, is a member of the inhibitor of apoptosis protein
(IAP) family known for its important conserved inhibitory effect on caspase activity. Since the …

As the ubiquitin–proteasome system (UPS) regulates almost every biological process, the
dysregulation or aberrant expression of the UPS components causes many pathological …

The aberrant protein sorting has been observed in many conditions, including complex
diseases, drug treatments, and environmental stresses. It is important to systematically …

Bortezomib (BTZ) is a first-in-class reversible and selective proteasome inhibitor. It inhibits
the ubiquitin proteasome pathway that leads to the degradation of many intracellular …

Drug resistance is a multifactorial process involving a variety of mechanisms and genes.
Taxane drug class like Docetaxel is not effective for all types' breast cancers and presents a …

The 2020 global cancer registry has ranked breast cancer (BCa) as the most commonly
diagnosed type of cancer and the most common cause of cancer-related deaths in women …

Lung cancer is one of the leading causes of cancer-related deaths in men and women
worldwide. Current treatments have limited efficacy, cause significant side effects, and cells …

Chondroitin sulfate (CS) is a food-derived bioactive substance with multiple biological
functions, which exists in animal cartilage and/or bone. Sturgeon, a type of cartilaginous fish …

Abstract Introduction: Changes in microRNAs (miRs) contribute to the alternative chemo-
resistance of cancers. Bortezomib (BTZ) is a well-characterized anticancer agent that inhibits …

Simple Summary c-FLIP is a master anti-apoptotic regulator associated with resistance to
various therapeutic options in different cancer types. Thus, exploring the combinatorial …