Squeezing for life–properties of red blood cell deformability

R Huisjes, A Bogdanova, WW Van Solinge… - Frontiers in …, 2018 - frontiersin.org
Deformability is an essential feature of blood cells (RBCs) that enables them to travel
through even the smallest capillaries of the human body. Deformability is a function of (i) …

Microfluidics: reframing biological enquiry

TA Duncombe, AM Tentori, AE Herr - Nature Reviews Molecular Cell …, 2015 - nature.com
The underlying physical properties of microfluidic tools have led to new biological insights
through the development of microsystems that can manipulate, mimic and measure biology …

Sa-unet: Spatial attention u-net for retinal vessel segmentation

C Guo, M Szemenyei, Y Yi, W Wang… - … conference on pattern …, 2021 - ieeexplore.ieee.org
The precise segmentation of retinal blood vessels is of great significance for early diagnosis
of eye-related diseases such as diabetes and hypertension. In this work, we propose a …

CRAUNet: A cascaded residual attention U-Net for retinal vessel segmentation

F Dong, D Wu, C Guo, S Zhang, B Yang… - Computers in Biology and …, 2022 - Elsevier
Retinal vessels play an important role in judging many eye-related diseases, so accurate
segmentation of retinal vessels has become the key to auxiliary diagnosis. In this paper, we …

Attention guided U-Net with atrous convolution for accurate retinal vessels segmentation

Y Lv, H Ma, J Li, S Liu - IEEE Access, 2020 - ieeexplore.ieee.org
The accuracy of retinal vessels segmentation is of great significance for the diagnosis of
cardiovascular diseases such as diabetes and hypertension. Especially, the segmentation …

Microfluidic organ/body-on-a-chip devices at the convergence of biology and microengineering

AR Perestrelo, ACP Águas, A Rainer, G Forte - Sensors, 2015 - mdpi.com
Recent advances in biomedical technologies are mostly related to the convergence of
biology with microengineering. For instance, microfluidic devices are now commonly found …

Microconstriction arrays for high-throughput quantitative measurements of cell mechanical properties

JR Lange, J Steinwachs, T Kolb, LA Lautscham… - Biophysical journal, 2015 - cell.com
We describe a method for quantifying the mechanical properties of cells in suspension with
a microfluidic device consisting of a parallel array of micron-sized constrictions. Using a high …

Glutaraldehyde–a subtle tool in the investigation of healthy and pathologic red blood cells

A Abay, G Simionato, R Chachanidze… - Frontiers in …, 2019 - frontiersin.org
Glutaraldehyde is a well-known substance used in biomedical research to fix cells. Since
hemolytic anemias are often associated with red blood cell shape changes deviating from …

Technologies for measuring red blood cell deformability

K Matthews, ES Lamoureux, ME Myrand-Lapierre… - Lab on a Chip, 2022 - pubs.rsc.org
Human red blood cells (RBCs) are approximately 8 μm in diameter, but must repeatedly
deform through capillaries as small as 2 μm in order to deliver oxygen to all parts of the …

Assessing red blood cell deformability from microscopy images using deep learning

ES Lamoureux, E Islamzada, MVJ Wiens, K Matthews… - Lab on a Chip, 2022 - pubs.rsc.org
Red blood cells (RBCs) must be highly deformable to transit through the microvasculature to
deliver oxygen to tissues. The loss of RBC deformability resulting from pathology, natural …