[HTML][HTML] From purines to purinergic signalling: molecular functions and human diseases

Z Huang, N Xie, P Illes, F Di Virgilio, H Ulrich… - … and Targeted Therapy, 2021 - nature.com
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …

[HTML][HTML] Carbohydrate-based drugs launched during 2000− 2021

X Cao, X Du, H Jiao, Q An, R Chen, P Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …

Update of P2Y receptor pharmacology: IUPHAR Review 27

KA Jacobson, EG Delicado, C Gachet… - British Journal of …, 2020 - Wiley Online Library
Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …

Molecular pharmacology of P2Y receptor subtypes

I von Kuegelgen - Biochemical Pharmacology, 2021 - Elsevier
Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …

[HTML][HTML] P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation

A Mansour, C Bachelot-Loza, N Nesseler… - International journal of …, 2020 - mdpi.com
The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …

Exploring the diverse applications of Carbohydrate macromolecules in food, pharmaceutical, and environmental technologies

K Ramaprabha, V Kumar, P Saravanan… - Environmental …, 2024 - Elsevier
Carbohydrates are a class of macromolecules that has significant potential across several
domains, including the organisation of genetic material, provision of structural support, and …

Pharmacology of P2Y receptors

I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …

Bridging free radical chemistry with drug discovery: A promising way for finding novel drugs efficiently

ZQ Liu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Many diseases have been regarded to correlate with the in vivo oxidative damages, which
are caused by overproduced free radicals from metabolic process or reactive oxygen …

[HTML][HTML] Pharmacological characterization of P2Y receptor subtypes–an update

I von Kügelgen - Purinergic Signalling, 2024 - Springer
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …

Agonists and antagonists for purinergic receptors

CE Müller, Y Baqi, V Namasivayam - Purinergic signaling: Methods and …, 2020 - Springer
Membrane receptors that are activated by the purine nucleoside adenosine (adenosine
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …