[HTML][HTML] From purines to purinergic signalling: molecular functions and human diseases
Purines and their derivatives, most notably adenosine and ATP, are the key molecules
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
controlling intracellular energy homoeostasis and nucleotide synthesis. Besides, these …
[HTML][HTML] Carbohydrate-based drugs launched during 2000− 2021
X Cao, X Du, H Jiao, Q An, R Chen, P Fang… - … Pharmaceutica Sinica B, 2022 - Elsevier
Carbohydrates are fundamental molecules involved in nearly all aspects of lives, such as
being involved in formating the genetic and energy materials, supporting the structure of …
being involved in formating the genetic and energy materials, supporting the structure of …
Update of P2Y receptor pharmacology: IUPHAR Review 27
KA Jacobson, EG Delicado, C Gachet… - British Journal of …, 2020 - Wiley Online Library
Eight G protein‐coupled P2Y receptor subtypes respond to extracellular adenine and uracil
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …
mononucleotides and dinucleotides. P2Y receptors belong to the δ group of rhodopsin‐like …
Molecular pharmacology of P2Y receptor subtypes
I von Kuegelgen - Biochemical Pharmacology, 2021 - Elsevier
Abstract Professor Geoffrey Burnstock proposed the concept of purinergic signaling via P1
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
and P2 receptors. P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular …
[HTML][HTML] P2Y12 Inhibition beyond Thrombosis: Effects on Inflammation
A Mansour, C Bachelot-Loza, N Nesseler… - International journal of …, 2020 - mdpi.com
The P2Y12 receptor is a key player in platelet activation and a major target for antithrombotic
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …
drugs. The beneficial effects of P2Y12 receptor antagonists might, however, not be restricted …
Exploring the diverse applications of Carbohydrate macromolecules in food, pharmaceutical, and environmental technologies
Carbohydrates are a class of macromolecules that has significant potential across several
domains, including the organisation of genetic material, provision of structural support, and …
domains, including the organisation of genetic material, provision of structural support, and …
Pharmacology of P2Y receptors
I von Kügelgen - Brain research bulletin, 2019 - Elsevier
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
nucleotides. There are eight mammalian P2Y receptor subtypes divided into two subgroups …
Bridging free radical chemistry with drug discovery: A promising way for finding novel drugs efficiently
ZQ Liu - European Journal of Medicinal Chemistry, 2020 - Elsevier
Many diseases have been regarded to correlate with the in vivo oxidative damages, which
are caused by overproduced free radicals from metabolic process or reactive oxygen …
are caused by overproduced free radicals from metabolic process or reactive oxygen …
[HTML][HTML] Pharmacological characterization of P2Y receptor subtypes–an update
I von Kügelgen - Purinergic Signalling, 2024 - Springer
Abstract P2Y receptors are G-protein-coupled receptors (GPCRs) for extracellular
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …
nucleotides. There are eight mammalian P2Y receptor subtypes (P2Y1, P2Y2, P2Y4, P2Y6 …
Agonists and antagonists for purinergic receptors
Membrane receptors that are activated by the purine nucleoside adenosine (adenosine
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …
receptors) or by purine or pyrimidine nucleotides (P2Y and P2X receptors) transduce …