Mycobacterium tuberculosis modulation of macrophage cell death is a well-documented
phenomenon, but its role during bacterial replication is less characterized. In this study, we …

The outcome of Mycobacterium tuberculosis infection and the immunological response to
the bacillus Calmette-Guerin (BCG) vaccine are highly variable in humans. Deciphering the …

In an accident later known as the Lübeck disaster, 251 neonates were orally given three
doses of the new Bacille Calmette–Guérin (BCG) antituberculosis (TB) vaccine …

SARS-CoV-2 has infected over 340 million people, prompting therapeutic research. While
genetic studies can highlight potential drug targets, understanding the heritability of SARS …

Certain individuals are able to resist Mycobacterium tuberculosis infection despite persistent
and intense exposure. These persons do not exhibit adaptive immune priming as measured …

Host-directed therapies are a relatively new and promising approach to treatment of
tuberculosis. Modulation of specific host immune pathways, including those that impact …

Inborn errors of IFN-γ immunity can underlie tuberculosis (TB). We report three patients from
two kindreds without EBV viremia or disease but with severe TB and inherited complete ITK …

The pathogenesis of tuberculosis (TB) remains poorly understood, as no more than 5–10%
of individuals infected with Mycobacterium tuberculosis go on developing clinical disease …

Abstract The Mycobacterium tuberculosis Complex (MTBC) consists of a clonal group of
several mycobacterial lineages pathogenic to a range of different mammalian hosts. In this …

Of the 1.8 billion people worldwide infected with Mycobacterium tuberculosis, 5–15% will
develop active tuberculosis (TB). Approximately half will progress to active TB within the first …