While individual primary immunodeficiency diseases (PIDs) are rare, collectively they
represent a significant burden of disease. Recent estimates show that about one million …

Tuberculosis (TB) is an ancient disease with an enormous global impact. Despite declining
global incidence, the diagnosis, phenotyping, and epidemiological investigation of TB …

Mycobacterium tuberculosis (Mtb) is one of the most successful human pathogens. Several
cytokines are known to increase virulence of bacterial pathogens, leading us to investigate …

Herein we describe the development, characterization and application of an electrochemical
sensor based on the use of Nafion/MWCNT-modified screen-printed carbon electrodes …

Chest is the commonest site of involvement by tuberculosis (TB) in children; lungs being the
most frequently affected region, followed by nodes, pleura and chest wall. It is difficult to …

Background Tuberculosis (TB), caused by the Mycobacterium tuberculosis complex (MTBC),
is a chronic infectious disease with both pulmonary and extrapulmonary forms. This study …

Because most humans resist Mycobacterium tuberculosis infection, there is a paucity of lung
samples to study. To address this gap, we infected Diversity Outbred mice with M …

The level of susceptibility to tuberculosis (TB) infection depends upon allelic variations in
numerous interacting genes. In our mouse model system, the whole-genome quantitative …

The KhoeSan populations are the earliest known indigenous inhabitants of southern Africa.
The relatively recent expansion of Bantu-speaking agropastoralists, as well as European …

Mycobacterium tuberculosis infects two billion people across the globe, and results in 8–9
million new tuberculosis (TB) cases and 1–1.5 million deaths each year. Most patients have …