Brain-derived neurotrophic factor in Alzheimer's disease and its pharmaceutical potential

L Gao, Y Zhang, K Sterling, W Song - Translational Neurodegeneration, 2022 - Springer
Synaptic abnormalities are a cardinal feature of Alzheimer's disease (AD) that are known to
arise as the disease progresses. A growing body of evidence suggests that pathological …

[HTML][HTML] Exercise training improves memory performance in older adults: a narrative review of evidence and possible mechanisms

P Babaei, HB Azari - Frontiers in human neuroscience, 2022 - frontiersin.org
As human life expectancy increases, cognitive decline and memory impairment threaten
independence and quality of life. Therefore, finding prevention and treatment strategies for …

Synthetic cannabinoids: a pharmacological and toxicological overview

R Roque-Bravo, RS Silva, RF Malheiro… - Annual Review of …, 2023 - annualreviews.org
Synthetic cannabinoids (SCs) are a chemically diverse group of new psychoactive
substances (NPSs) that target the endocannabinoid system, triggering a plethora of actions …

Improved cognition impairment by activating cannabinoid receptor type 2: Modulating CREB/BDNF expression and impeding TLR-4/NFκBp65/M1 microglia signaling …

SS Abd El-Rahman, HM Fayed - PLoS One, 2022 - journals.plos.org
Alzheimer's disease (AD) is characterized by an active inflammatory response induced by
the brain's deposition and accumulation of amyloid-beta (Aβ). Cannabinoid receptor type 2 …

Age-related perioperative neurocognitive disorders: experimental models and Druggable targets

OL Barreto Chang, KL Possin… - Annual review of …, 2023 - annualreviews.org
With the worldwide increase in life span, surgical patients are becoming older and have a
greater propensity for postoperative cognitive impairment, either new onset or through …

The role of BDNF as a biomarker in cognitive and sensory neurodegeneration

A Pisani, F Paciello, V Del Vecchio, R Malesci… - Journal of Personalized …, 2023 - mdpi.com
Brain-derived neurotrophic factor (BDNF) has a crucial function in the central nervous
system and in sensory structures including olfactory and auditory systems. Many studies …

[HTML][HTML] Dietary PUFAs and exercise dynamic actions on endocannabinoids in brain: consequences for neural plasticity and neuroinflammation

Y Park, BA Watkins - Advances in Nutrition, 2022 - Elsevier
The brain and peripheral nervous system provide oversight to muscle physiology and
metabolism. Muscle is the largest organ in the body and critical for glucose sensitivity …

Acupuncture alleviates CUMS‐induced depression‐like behaviors by restoring prefrontal cortex neuroplasticity

P Li, W Huang, Y Chen, MS Aslam, W Cheng… - Neural …, 2023 - Wiley Online Library
Purpose. To explore the therapeutic efficiency of acupuncture and the related molecular
mechanism of neural plasticity in depression. Methods. Chronic unpredictable mild stress …

Adult neurogenesis: a story ranging from controversial new neurogenic areas and human adult neurogenesis to molecular regulation

P Leal-Galicia, ME Chávez-Hernández, F Mata… - International journal of …, 2021 - mdpi.com
The generation of new neurons in the adult brain is a currently accepted phenomenon. Over
the past few decades, the subventricular zone and the hippocampal dentate gyrus have …

Can physical activity support the endocannabinoid system in the preventive and therapeutic approach to neurological disorders?

T Charytoniuk, H Zywno… - International journal of …, 2020 - mdpi.com
The worldwide prevalence of neurological and neurodegenerative disorders, such as
depression or Alzheimer's disease, has spread extensively throughout the last decades …