Stem cell homing is a multistep endogenous physiologic process that is also used by
exogenously administered hematopoietic stem and progenitor cells (HSPCs). This multistep …

CD44 is a cell adhesion molecule that plays an important role in tumor progression and
metastasis. The role of CD44 in tumorigenesis is due to its binding to extracellular matrix …

Cancer stem-like cells (CSC) play pivotal roles in both chemoresistance and recurrence of
many cancer types, including urothelial bladder cancer (UBC). In addition to intrinsic …

Accumulation and turnover of extracellular matrix is a hallmark of tissue injury, repair and
remodeling in human diseases. Hyaluronan is a major component of the extracellular matrix …

Hematopoietic stem cells (HSCs) are the life-long source of all types of blood cells. Their
function is controlled by their direct microenvironment, the HSC niche in the bone marrow …

Hyaluronic acid (HA) is a glycosaminoglycan that is found in extracellular tissue in many
parts of the body. It is a material of increasing importance to biomaterials science and is …

CD44 is a cell surface adhesion molecule, which is overexpressed on cancer stem cells.
The interaction of CD44 with hyaluronan is responsible for tumor development, metastasis …

Metastasis is the leading cause of cancer death, tumor progression proceeding through
emigration from the primary tumor, gaining access to the circulation, leaving the circulation …

Despite advances in new approaches for colorectal cancer (CRC) therapy, intravenous
chemotherapy remains one of the main treatment options; however, it has limitations …

Metastasis is a major contributor to cancer-associated deaths. It involves complex
interactions between primary tumorigenic sites and future metastatic sites. Accumulation …