Binding of transition metal ions to albumin: sites, affinities and rates
Background Serum albumin is the most abundant protein in the blood and cerebrospinal
fluid and plays a fundamental role in the distribution of essential transition metal ions in the …
fluid and plays a fundamental role in the distribution of essential transition metal ions in the …
Targeting cuproplasia and cuproptosis in cancer
Copper, an essential trace element that exists in oxidized and reduced forms, has pivotal
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …
roles in a variety of biological processes, including redox chemistry, enzymatic reactions …
Antimicrobial peptides and copper (II) ions: Novel therapeutic opportunities
J Portelinha, SS Duay, SI Yu, K Heilemann… - Chemical …, 2021 - ACS Publications
The emergence of new pathogens and multidrug resistant bacteria is an important public
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
health issue that requires the development of novel classes of antibiotics. Antimicrobial …
Hepcidin in human iron disorders: diagnostic implications
JJC Kroot, H Tjalsma, RE Fleming… - Clinical …, 2011 - academic.oup.com
BACKGROUND The peptide hormone hepcidin plays a central role in regulating dietary iron
absorption and body iron distribution. Many human diseases are associated with alterations …
absorption and body iron distribution. Many human diseases are associated with alterations …
Cellular mechanisms of cadmium toxicity related to the homeostasis of essential metals
JM Moulis - Biometals, 2010 - Springer
The widespread occurrence of cadmium in the environment continues to pose a threat to
human health despite attempts at limiting its technological uses. The biologically significant …
human health despite attempts at limiting its technological uses. The biologically significant …
[HTML][HTML] Intersection of iron and copper metabolism in the mammalian intestine and liver
Iron and copper have similar physiochemical properties; thus, physiologically relevant
interactions seem likely. Indeed, points of intersection between these two essential trace …
interactions seem likely. Indeed, points of intersection between these two essential trace …
Molecular mediators governing iron-copper interactions
S Gulec, JF Collins - Annual review of nutrition, 2014 - annualreviews.org
Given their similar physiochemical properties, it is a logical postulate that iron and copper
metabolism are intertwined. Indeed, iron-copper interactions were first documented over a …
metabolism are intertwined. Indeed, iron-copper interactions were first documented over a …
Antimicrobial metallopeptides
JL Alexander, Z Thompson, JA Cowan - ACS chemical biology, 2018 - ACS Publications
Antimicrobial peptides are short amphipathic peptides that are produced by the innate
immune system in order to protect a host from pathogens. They have been shown to have …
immune system in order to protect a host from pathogens. They have been shown to have …
Iron, hepcidin, and the metal connection
O Loréal, T Cavey, E Bardou-Jacquet… - Frontiers in …, 2014 - frontiersin.org
Identification of new players in iron metabolism, such as hepcidin, which regulates
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …
ferroportin and divalent metal transporter 1 expression, has improved our knowledge of iron …
Hepcidin, iron, and bacterial infection
JC Barton, RT Acton - Vitamins and hormones, 2019 - Elsevier
Hepcidin, an oligopeptide, has two major functions in mammals. Hepcidin regulates iron
homeostasis by controlling iron export from absorptive enterocytes, hepatocytes, and …
homeostasis by controlling iron export from absorptive enterocytes, hepatocytes, and …