Iron efflux from mammalian cells is supported by the synergistic actions of the ferrous iron
efflux transporter, ferroportin (Fpn) and a multicopper ferroxidase, that is, hephaestin (Heph) …

Aim Copper deficiency could cause fatal hematological and neurological disorders or other
diseases. Amino acids are involved in the absorption of copper ions. The purpose of this …

For over 100 years, there has been an incredible amount of knowledge amassed
concerning hormones in the endocrine system and their central role in human health …

Iron (Fe) is fundamental to life on earth. In the human body, it is both essential and harmful if
above threshold. A similar balance applies to other elements: calcium (Ca), magnesium …

Hepcidin is a peptide hormone that regulates the homeostasis of iron metabolism. The N-
terminal domain of hepcidin is conserved amongst a range of species and is capable of …

Although dietary iron is a determinant of iron status in animals, body fat mass has been
reported to have an inverse association with iron status in human studies. The goal of this …

Hepcidin 25 (hep 25) is a cysteine-rich 25-amino acid antimicrobial peptide containing the
amino-terminal Cu (II)/Ni (II)-binding (ATCUN) motif. Upon metal binding, the ATCUN motif is …

Hepcidin is an iron regulatory hormone, involved also in immune response in vertebrates. It
contains the N-terminal Asp-Thr-His site able to bind Cu (II) ions. A significant discrepancy …

Hepcidin-25 was identified as the main iron regulator in the human body, and it by binds to
the sole iron-exporter ferroportin. Studies showed that the N-terminus of hepcidin is …

Hepcidin is a principal regulator of iron homeostasis and its dysregulation has been
recognised as a causative factor in cancers and iron disorders. The strategy of manipulating …